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Spyre Therapeutics
SYRE

Overview Fund Activity

92 hedge funds and large institutions have $319M invested in Spyre Therapeutics in 2020 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 33 increasing their positions, 29 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
92
Holders Change
-2
Holders Change %
-2.13%
% of All Funds
1.63%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.05%
New
10
Increased
33
Reduced
29
Closed
12
Calls
$2K
Puts
$551K
Net Calls
-$549K
Net Calls Change
-$550K

Top Buyers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
+$23M
2
PAMU
Pictet Asset Management (UK)
United Kingdom
+$10.9M
3
Millennium Management
Millennium Management
New York
+$3.19M
4
SCM
Suvretta Capital Management
New York
+$1.81M
5
BlackRock
BlackRock
New York
+$883K

Top Sellers

1
NCM
Nantahala Capital Management
Connecticut
-$9.04M
2
BBA
Baker Bros. Advisors
New York
-$7.63M
3
OM
Opaleye Management
Massachusetts
-$2.66M
4
Renaissance Technologies
Renaissance Technologies
New York
-$2.34M
5
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
-$985K
Name Holding Trade Value Shares
Change 		Shares
Change %
ACM
26
Altium Capital Management
New York
$2.11M +$2.11M +10,710 New
A
27
Abingworth
United Kingdom
$1.89M – – –
SCM
28
Sio Capital Management
New York
$1.5M -$157K -800 -9%
RWM
29
Ritholtz Wealth Management
New York
$1.37M – – –
Nuveen Asset Management
30
Nuveen Asset Management
Illinois
$1.3M -$6.69K -34 -0.5%
Assenagon Asset Management
31
Assenagon Asset Management
Luxembourg
$1.27M +$311K +1,581 +33%
Bank of New York Mellon
32
Bank of New York Mellon
New York
$1.19M -$4.72K -24 -0.4%
Russell Investments Group
33
Russell Investments Group
United Kingdom
$1.11M -$193K -981 -15%
Morgan Stanley
34
Morgan Stanley
New York
$1.01M +$732K +3,720 +265%
Jacobs Levy Equity Management
35
Jacobs Levy Equity Management
New Jersey
$915K -$985K -5,008 -52%
Charles Schwab
36
Charles Schwab
California
$885K +$53.3K +271 +6%
YF
37
Yu Fan
$882K +$882K +4,482 New
D.E. Shaw & Co
38
D.E. Shaw & Co
New York
$879K +$137K +699 +19%
AG
39
Algert Global
California
$816K -$34.2K -174 -4%
California Public Employees Retirement System
40
California Public Employees Retirement System
California
$671K -$14.2K -72 -2%
FSA
41
Franklin Street Advisors
North Carolina
$578K – – –
California State Teachers Retirement System (CalSTRS)
42
California State Teachers Retirement System (CalSTRS)
California
$537K +$38.9K +198 +8%
Two Sigma Investments
43
Two Sigma Investments
New York
$506K -$602K -3,060 -54%
Two Sigma Advisers
44
Two Sigma Advisers
New York
$499K +$48.8K +248 +11%
State of Wisconsin Investment Board
45
State of Wisconsin Investment Board
Wisconsin
$475K -$59.1K -300 -11%
William Blair & Company
46
William Blair & Company
Illinois
$411K – – –
RhumbLine Advisers
47
RhumbLine Advisers
Massachusetts
$391K +$34.4K +175 +10%
Renaissance Technologies
48
Renaissance Technologies
New York
$387K -$2.34M -11,922 -86%
GCP
49
GSA Capital Partners
United Kingdom
$384K -$47.8K -243 -11%
UBS Group
50
UBS Group
Switzerland
$357K +$63.6K +323 +22%
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