Simplex Trading
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Simplex Trading’s Karyopharm Therapeutics KPTI Stock Holding History

Simplex Trading’s Portfolio KPTI Stock Details KPTI Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$874K Buy
156,900
+25,100
+19% +$191K ﹤0.01% 2650
2025
Q4 		$970K Buy
131,800
+83,600
+173% +$511K ﹤0.01% 2636
2025
Q3 		$315K Buy
+48,200
New +$259K ﹤0.01% 4394
2024
Q4 		– Sell
-147
Closed -$1K – 9102
2024
Q3 		$1K Sell
147
-6
-4% -$75 ﹤0.01% 8203
2024
Q2 		$1K Sell
153
-600
-80% -$9.93K ﹤0.01% 8484
2024
Q1 		$17K Sell
753
-847
-53% -$14.9K ﹤0.01% 7219
2023
Q4 		$20K Buy
+1,600
New +$21.6K ﹤0.01% 6933
2023
Q3 		– Sell
-267
Closed -$7K – 9263
2023
Q2 		$7K Sell
267
-140
-34% -$6.03K ﹤0.01% 7686
2023
Q1 		$23K Sell
407
-940
-70% -$46.4K ﹤0.01% 6780
2022
Q4 		$68K Buy
1,347
+340
+34% +$23.6K ﹤0.01% 5510
2022
Q3 		$82K Sell
1,007
-753
-43% -$56.2K ﹤0.01% 5791
2022
Q2 		$119K Buy
1,760
+7
+0.4% +$642 ﹤0.01% 5331
2022
Q1 		$193K Sell
1,753
-1,160
-40% -$145K ﹤0.01% 5201
2021
Q4 		$280K Buy
2,913
+2,300
+375% +$229K ﹤0.01% 4671
2021
Q3 		$97K Hold
613
– – ﹤0.01% 6655
2021
Q2 		$94K Buy
+613
New +$89K ﹤0.01% 6822
2021
Q1 		– Sell
-3
Closed -$72K – 9432
2020
Q4 		$72K Sell
3
-4
-57% -$927 ﹤0.01% 5776
2020
Q3 		$154K Buy
7
+2
+40% +$489 ﹤0.01% 4429
2020
Q2 		$140K Sell
5
-5
-50% -$1.48K ﹤0.01% 4418
2020
Q1 		$290K Sell
10
-28
-74% -$7.72K ﹤0.01% 3189
2019
Q4 		$1.1M Buy
38
+27
+245% +$5.86K ﹤0.01% 2006
2019
Q3 		$153K Sell
11
-12
-52% -$1.63K ﹤0.01% 3852
2019
Q2 		$207K Buy
23
+13
+130% +$1.04K ﹤0.01% 3436
2019
Q1 		$90K Hold
10
– – ﹤0.01% 4454
2018
Q4 		$133K Buy
10
+5
+100% +$843 ﹤0.01% 3563
2018
Q3 		$124K Buy
5
+4
+400% +$1.11K ﹤0.01% 4200
2018
Q2 		$37K Hold
1
– – ﹤0.01% 5366
2018
Q1 		$6K Buy
+1
New +$199 ﹤0.01% 4489
2017
Q4 		– Sell
-3
Closed -$2K – 6330
2017
Q3 		$2K Hold
3
– – ﹤0.01% 5086
2017
Q2 		$8K Sell
3
-31
-91% -$4.59K ﹤0.01% 4171
2017
Q1 		$70K Buy
34
+33
+3,300% +$5.3K ﹤0.01% 2061
2016
Q4 		$1K Sell
1
-1
-50% -$135 ﹤0.01% 5420
2016
Q3 		$1K Buy
+2
New +$240 ﹤0.01% 5348
2016
Q2 		– Hold
0
– – – 5322
2016
Q1 		– Hold
0
– – – 5139
2015
Q4 		– Sell
-1
Closed -$16K – 5770
2015
Q3 		$16K Sell
1
-1
-50% -$267 ﹤0.01% 3012
2015
Q2 		$13K Buy
+2
New +$864 ﹤0.01% 2841
2015
Q1 		– Sell
-3
Closed -$1.29K – 3226
2014
Q4 		$1K Buy
+3
New +$1.7K ﹤0.01% 4157

Other funds holding KPTI

CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return
APM
Avidity Partners Management Dallas, Texas $936M AUM 195% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
CCM
Catalio Capital Management New York $479M AUM 140.7% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
AAA
Affinity Asset Advisors New York $1.94B AUM 374.45% 1-Year Est. Return

Simplex Trading's KPTI Position: Q1 2026 in Review

Simplex Trading sold out of Karyopharm Therapeutics (KPTI) in Q1 2026, closing a stake of 32,868 shares — an estimated $251K sold.

Simplex Trading first reported a position in KPTI in Q4 2014 and held it in 30 quarters. The position peaked at $498K in Q4 2019. 77 funds tracked by Wall St. Rank hold KPTI as of Q1 2026.

  • Simplex Trading reported no remaining Karyopharm Therapeutics position as of Q1 2026 after selling out during the quarter.
  • Simplex Trading sold 32,868 Karyopharm Therapeutics shares in Q1 2026, an estimated $251K.
  • Simplex Trading first reported a position in Karyopharm Therapeutics in Q4 2014 and held it in 30 quarters.
  • Simplex Trading's Karyopharm Therapeutics position peaked at $498K in Q4 2019.
  • 77 funds tracked by Wall St. Rank held Karyopharm Therapeutics as of Q1 2026.

Based on Simplex Trading's 13F filing for Q1 2026, filed 14 May 2026.