Simplex Trading
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Simplex Trading’s Karyopharm Therapeutics KPTI Stock Holding History

Simplex Trading’s Portfolio KPTI Stock Details KPTI Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$1.51M Buy
270,700
+261,900
+2,976% +$2M ﹤0.01% 2080
2025
Q4 		$64.8K Sell
8,800
-17,800
-67% -$109K ﹤0.01% 5413
2025
Q3 		$173K Buy
26,600
+26,000
+4,333% +$140K ﹤0.01% 5120
2025
Q2 		$2K Sell
600
-63,700
-99% -$313K ﹤0.01% 8149
2025
Q1 		$240K Buy
64,300
+60,633
+1,653% +$518K ﹤0.01% 4131
2024
Q4 		$37K Sell
3,667
-6,813
-65% -$82.4K ﹤0.01% 6173
2024
Q3 		$130K Sell
10,480
-873
-8% -$10.8K ﹤0.01% 4958
2024
Q2 		$147K Buy
11,353
+9,600
+548% +$159K ﹤0.01% 4954
2024
Q1 		$39K Buy
1,753
+1,646
+1,538% +$28.9K ﹤0.01% 6499
2023
Q4 		$1K Sell
107
-66
-38% -$889 ﹤0.01% 8511
2023
Q3 		$3K Sell
173
-1,420
-89% -$31.9K ﹤0.01% 7912
2023
Q2 		$42K Buy
1,593
+960
+152% +$41.3K ﹤0.01% 6012
2023
Q1 		$36K Sell
633
-774
-55% -$38.2K ﹤0.01% 6293
2022
Q4 		$71K Buy
1,407
+180
+15% +$12.5K ﹤0.01% 5457
2022
Q3 		$100K Sell
1,227
-4,246
-78% -$317K ﹤0.01% 5528
2022
Q2 		$370K Sell
5,473
-2,120
-28% -$194K ﹤0.01% 3837
2022
Q1 		$839K Buy
7,593
+2,586
+52% +$322K ﹤0.01% 3124
2021
Q4 		$482K Buy
5,007
+4,120
+464% +$411K ﹤0.01% 3855
2021
Q3 		$141K Hold
887
– – ﹤0.01% 6126
2021
Q2 		$137K Buy
+887
New +$129K ﹤0.01% 6268
2021
Q1 		– Sell
-25
Closed -$585K – 9430
2020
Q4 		$585K Sell
25
-6
-19% -$1.39K ﹤0.01% 3214
2020
Q3 		$686K Buy
31
+13
+72% +$3.18K ﹤0.01% 2657
2020
Q2 		$520K Sell
18
-62
-78% -$18.3K ﹤0.01% 2852
2020
Q1 		$2.31M Buy
80
+33
+70% +$9.1K ﹤0.01% 1171
2019
Q4 		$1.36M Buy
47
+8
+21% +$1.74K ﹤0.01% 1811
2019
Q3 		$558K Buy
39
+31
+388% +$4.2K ﹤0.01% 2510
2019
Q2 		$71K Buy
8
+2
+33% +$161 ﹤0.01% 4528
2019
Q1 		$50K Buy
6
+4
+200% +$443 ﹤0.01% 5001
2018
Q4 		$32K Sell
2
-5
-71% -$843 ﹤0.01% 4956
2018
Q3 		$180K Buy
7
+5
+250% +$1.38K ﹤0.01% 3756
2018
Q2 		$59K Sell
2
-4
-67% -$989 ﹤0.01% 4869
2018
Q1 		$37K Buy
6
+4
+200% +$798 ﹤0.01% 2730
2017
Q4 		$6K Hold
2
– – ﹤0.01% 4339
2017
Q3 		$2K Sell
2
-10
-83% -$1.43K ﹤0.01% 5085
2017
Q2 		$27K Buy
12
+6
+100% +$888 ﹤0.01% 2990
2017
Q1 		$36K Buy
6
+1
+20% +$161 ﹤0.01% 2666
2016
Q4 		$3K Sell
5
-2
-29% -$270 ﹤0.01% 4749
2016
Q3 		$22K Buy
+7
New +$841 ﹤0.01% 2874
2016
Q2 		– Sell
-4
Closed -$1K – 6144
2016
Q1 		$1K Sell
4
-1
-20% -$110 ﹤0.01% 5138
2015
Q4 		$3K Buy
+5
New +$1.08K ﹤0.01% 4245
2015
Q2 		– Sell
-1
Closed -$3K – 5519
2015
Q1 		$3K Buy
+1
New +$431 ﹤0.01% 3856

Other funds holding KPTI

CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return
APM
Avidity Partners Management Dallas, Texas $936M AUM 195% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
CCM
Catalio Capital Management New York $479M AUM 140.7% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
AAA
Affinity Asset Advisors New York $1.94B AUM 374.45% 1-Year Est. Return

Simplex Trading's KPTI Position: Q1 2026 in Review

Simplex Trading sold out of Karyopharm Therapeutics (KPTI) in Q1 2026, closing a stake of 32,868 shares — an estimated $251K sold.

Simplex Trading first reported a position in KPTI in Q4 2014 and held it in 30 quarters. The position peaked at $498K in Q4 2019. 77 funds tracked by Wall St. Rank hold KPTI as of Q1 2026.

  • Simplex Trading reported no remaining Karyopharm Therapeutics position as of Q1 2026 after selling out during the quarter.
  • Simplex Trading sold 32,868 Karyopharm Therapeutics shares in Q1 2026, an estimated $251K.
  • Simplex Trading first reported a position in Karyopharm Therapeutics in Q4 2014 and held it in 30 quarters.
  • Simplex Trading's Karyopharm Therapeutics position peaked at $498K in Q4 2019.
  • 77 funds tracked by Wall St. Rank held Karyopharm Therapeutics as of Q1 2026.

Based on Simplex Trading's 13F filing for Q1 2026, filed 14 May 2026.