Simplex Trading
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Simplex Trading’s Karyopharm Therapeutics KPTI Stock Holding History

Simplex Trading’s Portfolio KPTI Stock Details KPTI Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$977 Sell
100
-270,600
-100% -$2.35M ﹤0.01% 8834
2026
Q1 		$1.51M Buy
270,700
+261,900
+2,976% +$2M ﹤0.01% 2080
2025
Q4 		$64.8K Sell
8,800
-17,800
-67% -$109K ﹤0.01% 5413
2025
Q3 		$173K Buy
26,600
+26,000
+4,333% +$140K ﹤0.01% 5120
2025
Q2 		$2K Sell
600
-63,700
-99% -$313K ﹤0.01% 8149
2025
Q1 		$240K Buy
64,300
+60,633
+1,653% +$518K ﹤0.01% 4131
2024
Q4 		$37K Sell
3,667
-6,813
-65% -$82.4K ﹤0.01% 6173
2024
Q3 		$130K Sell
10,480
-873
-8% -$10.8K ﹤0.01% 4958
2024
Q2 		$147K Buy
11,353
+9,600
+548% +$159K ﹤0.01% 4954
2024
Q1 		$39K Buy
1,753
+1,646
+1,538% +$28.9K ﹤0.01% 6499
2023
Q4 		$1K Sell
107
-66
-38% -$889 ﹤0.01% 8511
2023
Q3 		$3K Sell
173
-1,420
-89% -$31.9K ﹤0.01% 7912
2023
Q2 		$42K Buy
1,593
+960
+152% +$41.3K ﹤0.01% 6012
2023
Q1 		$36K Sell
633
-774
-55% -$38.2K ﹤0.01% 6293
2022
Q4 		$71K Buy
1,407
+180
+15% +$12.5K ﹤0.01% 5457
2022
Q3 		$100K Sell
1,227
-4,246
-78% -$317K ﹤0.01% 5528
2022
Q2 		$370K Sell
5,473
-2,120
-28% -$194K ﹤0.01% 3837
2022
Q1 		$839K Buy
7,593
+2,586
+52% +$322K ﹤0.01% 3124
2021
Q4 		$482K Buy
5,007
+4,120
+464% +$411K ﹤0.01% 3855
2021
Q3 		$141K Hold
887
– – ﹤0.01% 6126
2021
Q2 		$137K Buy
+887
New +$129K ﹤0.01% 6268
2021
Q1 		– Sell
-25
Closed -$585K – 9430
2020
Q4 		$585K Sell
25
-6
-19% -$1.39K ﹤0.01% 3214
2020
Q3 		$686K Buy
31
+13
+72% +$3.18K ﹤0.01% 2657
2020
Q2 		$520K Sell
18
-62
-78% -$18.3K ﹤0.01% 2852
2020
Q1 		$2.31M Buy
80
+33
+70% +$9.1K ﹤0.01% 1171
2019
Q4 		$1.36M Buy
47
+8
+21% +$1.74K ﹤0.01% 1811
2019
Q3 		$558K Buy
39
+31
+388% +$4.2K ﹤0.01% 2510
2019
Q2 		$71K Buy
8
+2
+33% +$161 ﹤0.01% 4528
2019
Q1 		$50K Buy
6
+4
+200% +$443 ﹤0.01% 5001
2018
Q4 		$32K Sell
2
-5
-71% -$843 ﹤0.01% 4956
2018
Q3 		$180K Buy
7
+5
+250% +$1.38K ﹤0.01% 3756
2018
Q2 		$59K Sell
2
-4
-67% -$989 ﹤0.01% 4869
2018
Q1 		$37K Buy
6
+4
+200% +$798 ﹤0.01% 2730
2017
Q4 		$6K Hold
2
– – ﹤0.01% 4339
2017
Q3 		$2K Sell
2
-10
-83% -$1.43K ﹤0.01% 5085
2017
Q2 		$27K Buy
12
+6
+100% +$888 ﹤0.01% 2990
2017
Q1 		$36K Buy
6
+1
+20% +$161 ﹤0.01% 2666
2016
Q4 		$3K Sell
5
-2
-29% -$270 ﹤0.01% 4749
2016
Q3 		$22K Buy
+7
New +$841 ﹤0.01% 2874
2016
Q2 		– Sell
-4
Closed -$1K – 6144
2016
Q1 		$1K Sell
4
-1
-20% -$110 ﹤0.01% 5138
2015
Q4 		$3K Buy
+5
New +$1.08K ﹤0.01% 4245
2015
Q2 		– Sell
-1
Closed -$3K – 5519
2015
Q1 		$3K Buy
+1
New +$431 ﹤0.01% 3856

Other funds holding KPTI

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $71.3B AUM 56.8% 1-Year Est. Return
ACA
Acorn Capital Advisors New York $366M AUM 474.6% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
CCM
Catalio Capital Management New York $532M AUM 171.17% 1-Year Est. Return
APM
Avidity Partners Management Dallas, Texas $624M AUM 250.2% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $153B AUM 38.14% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return

Simplex Trading's KPTI Position: Q2 2026 in Review

Simplex Trading opened a new position in Karyopharm Therapeutics (KPTI) in Q2 2026: 24,086 shares worth $235K. The stake represents ﹤0.01% of the portfolio and ranks #4503 among its holdings. This is a return to the name: Simplex Trading previously reported a position in KPTI as recently as Q4 2025.

Simplex Trading first reported a position in KPTI in Q4 2014 and has held it in 31 quarters since. The position peaked at $498K in Q4 2019. 97 funds tracked by Wall St. Rank hold KPTI as of Q2 2026.

  • Simplex Trading held 24,086 shares of Karyopharm Therapeutics worth $235K as of Q2 2026.
  • Karyopharm Therapeutics was a new Simplex Trading position in Q2 2026.
  • Karyopharm Therapeutics made up ﹤0.01% of Simplex Trading's portfolio in Q2 2026, its #4503 holding.
  • Simplex Trading first reported a position in Karyopharm Therapeutics in Q4 2014 and has held it in 31 quarters since.
  • Simplex Trading's Karyopharm Therapeutics position peaked at $498K in Q4 2019.
  • 97 funds tracked by Wall St. Rank held Karyopharm Therapeutics as of Q2 2026.

Based on Simplex Trading's 13F filing for Q2 2026, filed 12 Aug 2026.