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Spyre Therapeutics
SYRE

Overview Fund Activity

129 hedge funds and large institutions have $953M invested in Spyre Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 63 increasing their positions, 26 reducing their positions, and 17 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
–
Holders Change %
0%
% of All Funds
1.73%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
18
Increased
63
Reduced
26
Closed
17
Calls
$1.05M
Puts
$603K
Net Calls
+$446K
Net Calls Change
+$628K

Top Buyers

1
TCM
Tang Capital Management
California
+$17.2M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$10.2M
3
BBA
Baker Bros. Advisors
New York
+$9.38M
4
BlackRock
BlackRock
New York
+$6.51M
5
Morgan Stanley
Morgan Stanley
New York
+$5.02M

Top Sellers

1
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$15.4M
2
PA
Perceptive Advisors
New York
-$11.7M
3
DCM
Driehaus Capital Management
Illinois
-$9.46M
4
PBA
Paradigm Biocapital Advisors
New York
-$3.84M
5
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$2.89M
Name Holding Trade Value Shares
Change 		Shares
Change %
AAA
26
Affinity Asset Advisors
New York
$9.08M +$1.87M +125,000 +26%
EA
27
Emerald Advisers
Pennsylvania
$8.47M +$270K +18,036 +3%
Goldman Sachs
28
Goldman Sachs
New York
$7.84M +$4.89M +326,348 +166%
Blackstone Inc
29
Blackstone Inc
New York
$7.32M – – –
WP
30
Woodline Partners
California
$6.96M +$5.15K +344 +0.1%
UBS Group
31
UBS Group
Switzerland
$6.93M -$1.34M -89,380 -16%
Northern Trust
32
Northern Trust
Illinois
$6.54M +$854K +57,072 +15%
Charles Schwab
33
Charles Schwab
California
$6.26M +$537K +35,867 +9%
Bank of America
34
Bank of America
North Carolina
$5.93M -$460K -30,724 -7%
SL
35
Siren LLC
Connecticut
$5.52M – – –
Victory Capital Management
36
Victory Capital Management
Texas
$5.3M +$1.53M +102,270 +41%
Capital World Investors
37
Capital World Investors
California
$5.25M – – –
EMFAT
38
Emerald Mutual Fund Advisers Trust
Pennsylvania
$4.93M -$898K -59,992 -15%
Voloridge Investment Management
39
Voloridge Investment Management
Florida
$4.18M +$322K +21,488 +8%
CS
40
Candriam SCA
Luxembourg
$3.68M – – –
BNP Paribas Financial Markets
41
BNP Paribas Financial Markets
France
$3.34M +$2.51M +167,487 +300%
DTC
42
Deep Track Capital
Connecticut
$3.28M – – –
Barclays
43
Barclays
United Kingdom
$3.24M +$30.5K +2,040 +1%
CLGM
44
Capitolis Liquid Global Markets
New York
$2.74M +$2.74M +183,000 New
AC
45
Armistice Capital
New York
$2.57M -$419K -28,000 -14%
NL
46
Nuveen LLC
North Carolina
$2.02M -$75.8K -5,061 -4%
Bank of New York Mellon
47
Bank of New York Mellon
New York
$1.98M +$268K +17,910 +16%
Schroder Investment Management Group
48
Schroder Investment Management Group
United Kingdom
$1.97M +$320K +21,054 +19%
TD Asset Management
49
TD Asset Management
Ontario, Canada
$1.71M +$1.37M +91,600 +410%
HS
50
HighVista Strategies
Massachusetts
$1.69M +$264K +17,646 +19%
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