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Spyre Therapeutics
SYRE

Overview Fund Activity

84 hedge funds and large institutions have $328M invested in Spyre Therapeutics in 2021 Q1 according to their latest regulatory filings, with 3 funds opening new positions, 23 increasing their positions, 32 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
84
Holders Change
-8
Holders Change %
-8.7%
% of All Funds
1.48%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
3
Increased
23
Reduced
32
Closed
11
Calls
$340K
Puts
$119K
Net Calls
+$221K
Net Calls Change
+$770K

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$5.56M
2
SCM
Suvretta Capital Management
New York
+$4.82M
3
GPP
Great Point Partners
Connecticut
+$3.98M
4
Vanguard Group
Vanguard Group
Pennsylvania
+$1.76M
5
SCM
Sio Capital Management
New York
+$1.68M

Top Sellers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$11.3M
2
NCM
Nantahala Capital Management
Connecticut
-$2.08M
3
DCM
Driehaus Capital Management
Illinois
-$1.91M
4
Millennium Management
Millennium Management
New York
-$697K
5
Russell Investments Group
Russell Investments Group
United Kingdom
-$447K
Name Holding Trade Value Shares
Change 		Shares
Change %
LPC
26
Lion Point Capital
New York
$2.38M – – –
UOTTAIMCU
27
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$2.22M – – –
ACM
28
Altium Capital Management
New York
$2.12M – – –
A
29
Abingworth
United Kingdom
$1.9M – – –
Jacobs Levy Equity Management
30
Jacobs Levy Equity Management
New Jersey
$1.5M +$579K +2,926 +63%
DCM
31
Driehaus Capital Management
Illinois
$1.39M -$1.91M -9,651 -58%
RWM
32
Ritholtz Wealth Management
New York
$1.38M – – –
Nuveen Asset Management
33
Nuveen Asset Management
Illinois
$1.25M -$60K -303 -5%
Assenagon Asset Management
34
Assenagon Asset Management
Luxembourg
$1.17M -$104K -523 -8%
Bank of New York Mellon
35
Bank of New York Mellon
New York
$1.14M -$59.6K -301 -5%
YF
36
Yu Fan
$887K – – –
Morgan Stanley
37
Morgan Stanley
New York
$880K -$135K -680 -13%
Charles Schwab
38
Charles Schwab
California
$878K -$13.1K -66 -1%
FSA
39
Franklin Street Advisors
North Carolina
$821K +$239K +1,204 +41%
California Public Employees Retirement System
40
California Public Employees Retirement System
California
$676K – – –
Russell Investments Group
41
Russell Investments Group
United Kingdom
$668K -$447K -2,261 -40%
California State Teachers Retirement System (CalSTRS)
42
California State Teachers Retirement System (CalSTRS)
California
$541K – – –
AG
43
Algert Global
California
$529K -$292K -1,475 -36%
D.E. Shaw & Co
44
D.E. Shaw & Co
New York
$497K -$388K -1,959 -44%
State of Wisconsin Investment Board
45
State of Wisconsin Investment Board
Wisconsin
$478K – – –
William Blair & Company
46
William Blair & Company
Illinois
$413K – – –
UBS Group
47
UBS Group
Switzerland
$396K +$36.6K +185 +10%
RhumbLine Advisers
48
RhumbLine Advisers
Massachusetts
$367K -$26.7K -135 -7%
Bank of America
49
Bank of America
North Carolina
$314K +$207K +1,047 +194%
Barclays
50
Barclays
United Kingdom
$301K +$184K +929 +158%
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