SYRE icon

Spyre Therapeutics
SYRE

Overview Fund Activity

131 hedge funds and large institutions have $1.39B invested in Spyre Therapeutics in 2024 Q4 according to their latest regulatory filings, with 34 funds opening new positions, 63 increasing their positions, 20 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
131
Holders Change
+12
Holders Change %
+10.08%
% of All Funds
1.74%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
34
Increased
63
Reduced
20
Closed
21
Calls
$161K
Puts
$79K
Net Calls
+$82K
Net Calls Change
+$102K

Top Buyers

1
DCM
Driehaus Capital Management
Illinois
$65.3M
2
Fidelity Investments
Fidelity Investments
Massachusetts
$205M
3
JFG
Jefferies Financial Group
New York
$28.3M
4
BlackRock
BlackRock
New York
$79.1M
5
Goldman Sachs
Goldman Sachs
New York
$17.4M

Top Sellers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
$527K
2
DTC
Deep Track Capital
Connecticut
$5.1M
3
ACA
Avoro Capital Advisors
New York
$0
4
Walleye Capital
Walleye Capital
New York
$0
5
PA
Perceptive Advisors
New York
$59.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
KK
101
KLP Kapitalforvaltning
Norway
$182K +$182K +7,800 New
PFSRSONJ
102
Police & Firemen's Retirement System of New Jersey
New Jersey
$172K +$172K +7,378 New
Bank of America
103
Bank of America
North Carolina
$166K -$5.84M -250,655 -97%
Royal Bank of Canada
104
Royal Bank of Canada
Ontario, Canada
$94K +$5.52K +236 +6%
AIP
105
Ameritas Investment Partners
Nebraska
$79K – – –
VEA
106
Virtus ETF Advisers
New York
$69.2K +$2.89K +124 +4%
A
107
AlphaQuest
New York
$51.2K -$80.5K -3,456 -61%
Mirae Asset Global Investments
108
Mirae Asset Global Investments
South Korea
$46.3K +$46.3K +1,955 New
Public Employees Retirement Association of Colorado
109
Public Employees Retirement Association of Colorado
Colorado
$37K – – –
HNB
110
Huntington National Bank
Ohio
$34.2K +$34.2K +1,470 New
GFM
111
GF Fund Management
China
$28.7K +$28.7K +1,232 New
AB
112
Amalgamated Bank
New York
$28K – – –
SCM
113
Sterling Capital Management
North Carolina
$23.5K +$20.8K +894 +777%
RS
114
R Squared
Hong Kong
$16.5K +$16.5K +710 New
VWM
115
Venturi Wealth Management
Texas
$5.38K +$5.38K +231 New
SMAM
116
Sugar Maple Asset Management
Wisconsin
$4.19K +$4.19K +180 New
Nisa Investment Advisors
117
Nisa Investment Advisors
Missouri
$2.79K +$210 +9 +8%
BIG
118
Brooklyn Investment Group
New York
$2.79K +$2.79K +120 New
IA
119
IFP Advisors
Florida
$2.77K -$127 -5 -4%
Osaic Holdings
120
Osaic Holdings
Arizona
$2.44K +$512 +22 +27%
S
121
SignatureFD
Georgia
$1.58K +$1.58K +68 New
Simplex Trading
122
Simplex Trading
Illinois
$1K +$1K +55 New
RIL
123
Rothschild Investment LLC
Illinois
$931 – – –
Amundi
124
Amundi
France
$769 +$769 +32 New
CIAM
125
Caitong International Asset Management
Hong Kong
$326 +$326 +14 New
2 3 4
5
6