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Spyre Therapeutics
SYRE

Overview Fund Activity

129 hedge funds and large institutions have $1B invested in Spyre Therapeutics in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 52 increasing their positions, 35 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
-2
Holders Change %
-1.53%
% of All Funds
1.75%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
20
Increased
52
Reduced
35
Closed
21
Calls
$827K
Puts
$1.01M
Net Calls
-$182K
Net Calls Change
-$264K

Top Buyers

1
Capital International Investors
Capital International Investors
California
+$38.6M
2
TCM
Tang Capital Management
California
+$33.1M
3
PBA
Paradigm Biocapital Advisors
New York
+$9.68M
4
Bank of America
Bank of America
North Carolina
+$6.78M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$3.83M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$15.3M
2
LGM
Logos Global Management
California
-$11.6M
3
BCM
Boxer Capital Management
California
-$10.9M
4
Goldman Sachs
Goldman Sachs
New York
-$8.88M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$7.45M
Name Holding Trade Value Shares
Change 		Shares
Change %
Invesco
76
Invesco
Georgia
$407K +$89.5K +5,544 +28%
MIM
77
MetLife Investment Management
New Jersey
$383K +$37.9K +2,351 +11%
Assenagon Asset Management
78
Assenagon Asset Management
Luxembourg
$367K +$1.19K +74 +0.3%
TD Asset Management
79
TD Asset Management
Ontario, Canada
$361K -$687K -42,600 -66%
IIM
80
INTECH Investment Management
Florida
$330K +$103K +6,385 +45%
CF
81
Corebridge Financial
Texas
$316K +$38.4K +2,382 +14%
NC
82
NBW Capital
Massachusetts
$314K – – –
WA
83
Waverly Advisors
Alabama
$314K +$314K +19,430 New
GEM
84
Global Endowment Management
North Carolina
$293K – – –
Natixis Advisors
85
Natixis Advisors
Massachusetts
$265K -$14.5K -899 -5%
ECM
86
ExodusPoint Capital Management
New York
$243K -$26.4K -1,636 -10%
ACM
87
ADAR1 Capital Management
Texas
$243K +$243K +15,033 New
PA
88
Profund Advisors
Maryland
$237K -$3.23K -200 -1%
ACM
89
Aquatic Capital Management
Illinois
$208K +$18.3K +1,136 +10%
CUAMC
90
China Universal Asset Management Company
China
$195K -$5.7K -353 -3%
ProShare Advisors
91
ProShare Advisors
Maryland
$184K -$18.6K -1,153 -9%
VOYA Investment Management
92
VOYA Investment Management
Georgia
$167K -$2.37K -147 -1%
New York State Common Retirement Fund
93
New York State Common Retirement Fund
New York
$166K – – –
ASRS
94
Arizona State Retirement System
Arizona
$162K -$1.58K -98 -1%
PFSRSONJ
95
Police & Firemen's Retirement System of New Jersey
New Jersey
$141K +$22.4K +1,389 +19%
KK
96
KLP Kapitalforvaltning
Norway
$126K – – –
SG Americas Securities
97
SG Americas Securities
New York
$115K +$115K +7,122 New
VIA
98
Virtus Investment Advisers
Connecticut
$111K +$111K +6,861 New
AIP
99
Ameritas Investment Partners
Nebraska
$65.3K +$10.6K +654 +19%
A
100
AlphaQuest
New York
$51.5K +$16K +993 +45%
2 3
4
5 6