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Spyre Therapeutics
SYRE

Overview Fund Activity

103 hedge funds and large institutions have $1.21B invested in Spyre Therapeutics in 2024 Q1 according to their latest regulatory filings, with 55 funds opening new positions, 20 increasing their positions, 15 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
103
Holders Change
+49
Holders Change %
+90.74%
% of All Funds
1.49%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.07%
New
55
Increased
20
Reduced
15
Closed
6
Calls
$76K
Puts
–
Net Calls
+$76K
Net Calls Change
+$32K

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$105M
2
BlackRock
BlackRock
New York
+$20.4M
3
DGM
Darwin Global Management
Jersey
+$17.9M
4
FCM
Farallon Capital Management
California
+$17.7M
5
FTM
First Turn Management
California
+$17.6M

Top Sellers

1
DTC
Deep Track Capital
Connecticut
-$28M
2
CAM
Cormorant Asset Management
Massachusetts
-$26.1M
3
EC
EcoR1 Capital
California
-$19.1M
4
GEM
Global Endowment Management
North Carolina
-$18.8M
5
HS
HighVista Strategies
Massachusetts
-$16.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
New York State Common Retirement Fund
76
New York State Common Retirement Fund
New York
$556K +$542K +14,305 +3,919%
State of Wisconsin Investment Board
77
State of Wisconsin Investment Board
Wisconsin
$555K +$555K +14,632 New
Janus Henderson Group
78
Janus Henderson Group
United Kingdom
$530K +$530K +13,977 New
Two Sigma Investments
79
Two Sigma Investments
New York
$507K -$559K -14,740 -52%
SRL
80
Scientech Research LLC
New Jersey
$499K +$499K +13,143 New
LCM
81
Legato Capital Management
California
$435K +$435K +11,458 New
EAM
82
EFG Asset Management
Oregon
$423K +$423K +11,151 New
LP
83
LMR Partners
United Kingdom
$421K +$421K +11,093 New
PCMH
84
Polymer Capital Management (HK)
Hong Kong
$399K +$399K +10,520 New
CG
85
Carlyle Group
District of Columbia
$365K – – –
Squarepoint
86
Squarepoint
New York
$310K +$310K +8,161 New
SFI
87
Susquehanna Fundamental Investments
Pennsylvania
$306K +$306K +8,075 New
Jane Street
88
Jane Street
New York
$273K +$273K +7,210 New
CIP
89
Chartwell Investment Partners
Pennsylvania
$259K +$259K +6,835 New
Bank of New York Mellon
90
Bank of New York Mellon
New York
$229K +$229K +6,050 New
VEA
91
Virtus ETF Advisers
New York
$221K -$15.2K -401 -6%
ASRS
92
Arizona State Retirement System
Arizona
$207K +$207K +5,445 New
TRCT
93
Tower Research Capital (TRC)
New York
$145K +$47.3K +1,248 +48%
UBS Group
94
UBS Group
Switzerland
$98.7K -$42.7K -1,125 -30%
Wells Fargo
95
Wells Fargo
California
$85K +$84.2K +2,219 +9,648%
Deutsche Bank
96
Deutsche Bank
Germany
$11.3K +$11.3K +298 New
IA
97
IFP Advisors
Florida
$4.32K – – –
Osaic Holdings
98
Osaic Holdings
Arizona
$3.15K -$7.58K -200 -71%
Royal Bank of Canada
99
Royal Bank of Canada
Ontario, Canada
$2K +$2K +56 New
PD
100
Point72 (DIFC)
United Arab Emirates
$847 +$847 +22 New
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4
5