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Spyre Therapeutics
SYRE

Overview Fund Activity

92 hedge funds and large institutions have $319M invested in Spyre Therapeutics in 2020 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 33 increasing their positions, 29 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
92
Holders Change
-2
Holders Change %
-2.13%
% of All Funds
1.63%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.05%
New
10
Increased
33
Reduced
29
Closed
12
Calls
$2K
Puts
$551K
Net Calls
-$549K
Net Calls Change
-$550K

Top Buyers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
+$23M
2
PAMU
Pictet Asset Management (UK)
United Kingdom
+$10.9M
3
Millennium Management
Millennium Management
New York
+$3.19M
4
SCM
Suvretta Capital Management
New York
+$1.81M
5
BlackRock
BlackRock
New York
+$883K

Top Sellers

1
NCM
Nantahala Capital Management
Connecticut
-$9.04M
2
BBA
Baker Bros. Advisors
New York
-$7.63M
3
OM
Opaleye Management
Massachusetts
-$2.66M
4
Renaissance Technologies
Renaissance Technologies
New York
-$2.34M
5
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
-$985K
Name Holding Trade Value Shares
Change 		Shares
Change %
MIM
76
MetLife Investment Management
New Jersey
$62.9K -$95.3K -485 -60%
Legal & General Group
77
Legal & General Group
United Kingdom
$38K – – –
AA
78
AlphaCentric Advisors
Puerto Rico
$31K +$7.75K +40 +33%
AIP
79
Ameritas Investment Partners
Nebraska
$29K – – –
IA
80
IFP Advisors
Florida
$20K – – –
Royal Bank of Canada
81
Royal Bank of Canada
Ontario, Canada
$15K +$13.4K +67 +838%
OSAM
82
O'Shaughnessy Asset Management
Connecticut
$13K +$13K +66 New
QCG
83
Quadrant Capital Group
Ohio
$9K – – –
PCM
84
Penserra Capital Management
California
$8K +$5.27K +29 +193%
SB
85
Samsara BioCapital
California
$6.96K – – –
Group One Trading
86
Group One Trading
Illinois
$2K +$1K +4 +100%
Daiwa Securities Group
87
Daiwa Securities Group
Japan
$1K -$1.5K -6 -60%
EI
88
Ellevest Inc
New York
$1K – – –
PWPS
89
Pinnacle Wealth Planning Services
Ohio
$1K +$1K +6 New
AIG
90
American International Group
New York
$207 +$9 +46 +5%
OM
91
Opaleye Management
Massachusetts
– -$2.66M -15,000 Closed
SCA
92
Snowden Capital Advisors
New York
– -$407K -2,299 Closed
Squarepoint
93
Squarepoint
New York
– -$285K -1,608 Closed
AAP
94
Ardsley Advisory Partners
Connecticut
– -$217K -1,224 Closed
Prudential Financial
95
Prudential Financial
New Jersey
– -$112K -632 Closed
EGM
96
Engineers Gate Manager
New York
– -$102K -576 Closed
Arrowstreet Capital
97
Arrowstreet Capital
Massachusetts
– -$89K -504 Closed
Jane Street
98
Jane Street
New York
– -$84K -475 Closed
BFM
99
Boothbay Fund Management
New York
– -$75K -423 Closed
Osaic Holdings
100
Osaic Holdings
Arizona
– -$6K -31 Closed
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