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Spyre Therapeutics
SYRE

Overview Fund Activity

103 hedge funds and large institutions have $1.21B invested in Spyre Therapeutics in 2024 Q1 according to their latest regulatory filings, with 55 funds opening new positions, 20 increasing their positions, 15 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
103
Holders Change
+49
Holders Change %
+90.74%
% of All Funds
1.49%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.07%
New
55
Increased
20
Reduced
15
Closed
6
Calls
$76K
Puts
–
Net Calls
+$76K
Net Calls Change
+$32K

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$105M
2
BlackRock
BlackRock
New York
+$20.4M
3
DGM
Darwin Global Management
Jersey
+$17.9M
4
FCM
Farallon Capital Management
California
+$17.7M
5
FTM
First Turn Management
California
+$17.6M

Top Sellers

1
DTC
Deep Track Capital
Connecticut
-$28M
2
CAM
Cormorant Asset Management
Massachusetts
-$26.1M
3
EC
EcoR1 Capital
California
-$19.1M
4
GEM
Global Endowment Management
North Carolina
-$18.8M
5
HS
HighVista Strategies
Massachusetts
-$16.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
ACM
51
ADAR1 Capital Management
Texas
$1.88M +$1.63M +43,060 +669%
Renaissance Technologies
52
Renaissance Technologies
New York
$1.88M +$35.3K +932 +2%
CSS
53
Cubist Systematic Strategies
Connecticut
$1.87M +$878K +23,153 +89%
Barclays
54
Barclays
United Kingdom
$1.74M +$17.6K +464 +1%
Swiss National Bank
55
Swiss National Bank
Switzerland
$1.48M +$1.48M +39,100 New
Bank of America
56
Bank of America
North Carolina
$1.38M +$1.38M +36,332 New
SSA
57
Schonfeld Strategic Advisors
New York
$1.35M +$1.35M +35,500 New
NC
58
NBW Capital
Massachusetts
$1.3M +$1.3M +34,360 New
Balyasny Asset Management
59
Balyasny Asset Management
Illinois
$1.23M +$1.23M +32,397 New
Allianz Asset Management
60
Allianz Asset Management
Germany
$1.21M +$1.21M +31,800 New
Citigroup
61
Citigroup
New York
$1.2M +$814K +21,460 +208%
SFM
62
Soros Fund Management
New York
$1.14M +$1.14M +30,038 New
Manulife (Manufacturers Life Insurance)
63
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$935K +$935K +24,657 New
ECM
64
ExodusPoint Capital Management
New York
$928K -$65.9K -1,738 -7%
JF
65
Jump Financial
Illinois
$865K +$865K +22,800 New
CS
66
Credit Suisse
Switzerland
$837K +$837K +22,056 New
Blackstone Inc
67
Blackstone Inc
New York
$758K – – –
GEM
68
Global Endowment Management
North Carolina
$690K -$18.8M -495,252 -96%
FAM
69
Fred Alger Management
New York
$689K +$689K +18,158 New
EI
70
EAM Investors
California
$680K +$680K +17,938 New
California State Teachers Retirement System (CalSTRS)
71
California State Teachers Retirement System (CalSTRS)
California
$675K +$675K +17,803 New
Legal & General Group
72
Legal & General Group
United Kingdom
$646K +$646K +17,032 New
VF
73
Virtu Financial
New York
$615K +$615K +16,213 New
EGM
74
Engineers Gate Manager
New York
$594K +$594K +15,653 New
Charles Schwab
75
Charles Schwab
California
$569K +$569K +15,000 New
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