Spyre Therapeutics
SYRE
SYRE
129 hedge funds and large institutions have $1B invested in Spyre Therapeutics in 2025 Q1 according to their latest regulatory filings, with 19 funds opening new positions, 53 increasing their positions, 35 reducing their positions, and 21 closing their positions.
New
Increased
Maintained
Reduced
Closed
more repeat investments, than reductions
Existing positions increased: | Existing positions reduced:
more ownership
Funds ownership: →
less first-time investments, than exits
New positions opened: | Existing positions closed:
less funds holding
Funds holding: →
18% less call options, than puts
Call options by funds: $827K | Put options by funds: $1.01M
28% less capital invested
Capital invested by funds: $1.39B → $1B (-$390M)
50% less funds holding in top 10
Funds holding in top 10: 4 → 2 (-2)
Holders
129
Holding in Top 10
2
Calls
$827K
Puts
$1.01M
Top Buyers
| 1 | +$38.6M | |
| 2 | +$33.1M | |
| 3 | +$9.68M | |
| 4 |
Bank of America
Charlotte,
North Carolina
|
+$6.78M |
| 5 |
Fidelity Investments
Boston,
Massachusetts
|
+$3.83M |
Top Sellers
| 1 | -$15.3M | |
| 2 | -$11.6M | |
| 3 | -$10.9M | |
| 4 |
Goldman Sachs
New York
|
-$8.88M |
| 5 |
Janus Henderson Group
London,
United Kingdom
|
-$7.45M |