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Spyre Therapeutics
SYRE

Overview Fund Activity

129 hedge funds and large institutions have $1B invested in Spyre Therapeutics in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 52 increasing their positions, 35 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
-2
Holders Change %
-1.53%
% of All Funds
1.75%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
20
Increased
52
Reduced
35
Closed
21
Calls
$827K
Puts
$1.01M
Net Calls
-$182K
Net Calls Change
-$264K

Top Buyers

1
Capital International Investors
Capital International Investors
California
+$38.6M
2
TCM
Tang Capital Management
California
+$33.1M
3
PBA
Paradigm Biocapital Advisors
New York
+$9.68M
4
Bank of America
Bank of America
North Carolina
+$6.78M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$3.83M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$15.3M
2
LGM
Logos Global Management
California
-$11.6M
3
BCM
Boxer Capital Management
California
-$10.9M
4
Goldman Sachs
Goldman Sachs
New York
-$8.88M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$7.45M
Name Holding Trade Value Shares
Change 		Shares
Change %
AAA
26
Affinity Asset Advisors
New York
$7.77M -$5.53M -342,650 -42%
WP
27
Woodline Partners
California
$7.5M +$1.81M +112,128 +32%
DM
28
Deerfield Management
New York
$7.26M – – –
Bank of America
29
Bank of America
North Carolina
$6.89M +$6.78M +419,933 +5,880%
EMFAT
30
Emerald Mutual Fund Advisers Trust
Pennsylvania
$6.28M +$49K +3,038 +0.8%
Charles Schwab
31
Charles Schwab
California
$6.17M +$48.2K +2,986 +0.8%
Northern Trust
32
Northern Trust
Illinois
$6.13M +$498K +30,892 +9%
SL
33
Siren LLC
Connecticut
$5.95M -$87.2K -5,402 -1%
Capital World Investors
34
Capital World Investors
California
$5.66M -$449K -27,799 -7%
Morgan Stanley
35
Morgan Stanley
New York
$5.41M +$1.29M +80,211 +31%
Voloridge Investment Management
36
Voloridge Investment Management
Florida
$4.15M +$2.29M +141,962 +123%
Victory Capital Management
37
Victory Capital Management
Texas
$4.06M -$262K -16,230 -6%
T. Rowe Price Associates
38
T. Rowe Price Associates
Maryland
$4.01M -$4.16M -257,908 -51%
CS
39
Candriam SCA
Luxembourg
$3.97M -$25.2K -1,561 -0.6%
DTC
40
Deep Track Capital
Connecticut
$3.53M – – –
Barclays
41
Barclays
United Kingdom
$3.46M +$1.48M +91,535 +74%
AC
42
Armistice Capital
New York
$3.23M – – –
Goldman Sachs
43
Goldman Sachs
New York
$3.18M -$8.88M -550,484 -74%
NL
44
Nuveen LLC
North Carolina
$2.26M +$2.26M +140,129 New
SC
45
Stempoint Capital
New York
$2.2M +$2.2M +136,139 New
Citadel Advisors
46
Citadel Advisors
Florida
$2.11M -$15.3M -948,423 -88%
SFM
47
Soros Fund Management
New York
$2.02M -$2.02M -125,000 -50%
Schroder Investment Management Group
48
Schroder Investment Management Group
United Kingdom
$1.95M -$91.8K -5,116 -5%
Universal-Beteiligungs- und Servicegesellschaft
49
Universal-Beteiligungs- und Servicegesellschaft
Germany
$1.94M -$29.6K -1,832 -1%
Bank of New York Mellon
50
Bank of New York Mellon
New York
$1.84M +$170K +10,552 +10%
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