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Spyre Therapeutics
SYRE

Overview Fund Activity

50 hedge funds and large institutions have $19.2M invested in Spyre Therapeutics in 2022 Q4 according to their latest regulatory filings, with 8 funds opening new positions, 12 increasing their positions, 11 reducing their positions, and 13 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
50
Holders Change
-5
Holders Change %
-9.09%
% of All Funds
0.81%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
8
Increased
12
Reduced
11
Closed
13
Calls
$11K
Puts
–
Net Calls
+$11K
Net Calls Change
+$3K

Top Buyers

1
Millennium Management
1
Millennium Management
New York
$1.41M
2
PVI
2
Pura Vida Investments
New York
$472K
3
Acadian Asset Management
3
Acadian Asset Management
Massachusetts
$625K
4
NCM
4
Nantahala Capital Management
Connecticut
$2.07M
5
SFM
5
Sphera Funds Management
Israel
$198K

Top Sellers

1
PAMS
1
Pictet Asset Management (Switzerland)
Switzerland
$0
2
GPP
2
Great Point Partners
Connecticut
$0
3
SCM
3
Sio Capital Management
New York
$1.35M
4
Goldman Sachs
4
Goldman Sachs
New York
$0
5
BlackRock
5
BlackRock
New York
$291K
Name Holding Trade Value Shares
Change 		Shares
Change %
BCM
26
Bridgeway Capital Management
Texas
$67.5K +$67.5K +6,000 New
YF
27
Yu Fan
$50.4K – – –
FSA
28
Franklin Street Advisors
North Carolina
$48K – – –
ECM
29
ExodusPoint Capital Management
New York
$47K +$47K +4,210 New
Northern Trust
30
Northern Trust
Illinois
$38.9K +$7.75K +689 +25%
Morgan Stanley
31
Morgan Stanley
New York
$36.2K -$39.5K -3,512 -52%
William Blair & Company
32
William Blair & Company
Illinois
$34.5K – – –
RWM
33
Ritholtz Wealth Management
New York
$34.4K – – –
IA
34
IFP Advisors
Florida
$29K – – –
Susquehanna International Group
35
Susquehanna International Group
Pennsylvania
$22.9K +$22.9K +2,038 New
HF
36
HRT Financial
New York
$22K +$22K +1,999 New
Franklin Resources
37
Franklin Resources
California
$14.1K – – –
Bank of New York Mellon
38
Bank of New York Mellon
New York
$10.5K – – –
TRCT
39
Tower Research Capital (TRC)
New York
$8K -$4.05K -361 -34%
Prudential Financial
40
Prudential Financial
New Jersey
$7.74K +$7.74K +688 New
Bank of America
41
Bank of America
North Carolina
$7.08K +$1.84K +164 +35%
Citadel Advisors
42
Citadel Advisors
Florida
$6.96K -$20.4K -1,812 -75%
E
43
Ergoteles
New York
$6.62K +$6.62K +589 New
TSS
44
Two Sigma Securities
New York
$5.07K -$8.89K -791 -64%
Group One Trading
45
Group One Trading
Illinois
$1.43K +$34 +3 +2%
BNP Paribas Financial Markets
46
BNP Paribas Financial Markets
France
$1.34K +$628 +56 +89%
Wells Fargo
47
Wells Fargo
California
$1.15K +$11 +1 +1%
UBS Group
48
UBS Group
Switzerland
$4 – – –
PAMS
49
Pictet Asset Management (Switzerland)
Switzerland
– -$1.34M -101,717 Closed
GPP
50
Great Point Partners
Connecticut
– -$1.32M -100,000 Closed
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