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Two Sigma Securities’s Spyre Therapeutics SYRE Stock Holding History

Two Sigma Securities’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$267K Sell
3,003
-3,848
-56% -$281K 0.02% 959
2026
Q1 		$346K Buy
+6,851
New +$258K 0.04% 680
2023
Q1 		– Sell
-451
Closed -$5.07K – 3247
2022
Q4 		$5.07K Sell
451
-791
-64% -$14.2K ﹤0.01% 2450
2022
Q3 		$16K Buy
+1,242
New +$15.3K ﹤0.01% 2331

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Two Sigma Securities's SYRE Position: Q2 2026 in Review

Two Sigma Securities reduced its Spyre Therapeutics (SYRE) stake by 56% in Q2 2026, selling an estimated $281K and leaving 3,003 shares worth $267K. The position accounts for 0.02% of the portfolio, ranked #959.

Two Sigma Securities first reported a position in SYRE in Q3 2022 and has held it in 4 quarters since. The position peaked at $346K in Q1 2026. 265 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • Two Sigma Securities held 3,003 shares of Spyre Therapeutics worth $267K as of Q2 2026.
  • Two Sigma Securities sold 3,848 Spyre Therapeutics shares in Q2 2026, an estimated $281K.
  • Spyre Therapeutics made up 0.02% of Two Sigma Securities's portfolio in Q2 2026, its #959 holding.
  • Two Sigma Securities first reported a position in Spyre Therapeutics in Q3 2022 and has held it in 4 quarters since.
  • Two Sigma Securities's Spyre Therapeutics position peaked at $346K in Q1 2026.
  • 265 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on Two Sigma Securities's 13F filing for Q2 2026, filed 14 Aug 2026.