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Spyre Therapeutics
SYRE

Overview Fund Activity

131 hedge funds and large institutions have $1.39B invested in Spyre Therapeutics in 2024 Q4 according to their latest regulatory filings, with 34 funds opening new positions, 63 increasing their positions, 20 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
131
Holders Change
+12
Holders Change %
+10.08%
% of All Funds
1.74%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
34
Increased
63
Reduced
20
Closed
21
Calls
$161K
Puts
$79K
Net Calls
+$82K
Net Calls Change
+$102K

Top Buyers

1
DCM
Driehaus Capital Management
Illinois
$65.3M
2
Fidelity Investments
Fidelity Investments
Massachusetts
$205M
3
JFG
Jefferies Financial Group
New York
$28.3M
4
BlackRock
BlackRock
New York
$79.1M
5
Goldman Sachs
Goldman Sachs
New York
$17.4M

Top Sellers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
$527K
2
DTC
Deep Track Capital
Connecticut
$5.1M
3
ACA
Avoro Capital Advisors
New York
$0
4
Walleye Capital
Walleye Capital
New York
$0
5
PA
Perceptive Advisors
New York
$59.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
AF
126
Allworth Financial
California
$197 +$44 +2 +29%
PCWA
127
Pacific Capital Wealth Advisors
California
$186 – – –
EWA
128
EverSource Wealth Advisors
Alabama
$186 +$186 +8 New
SS
129
SBI Securities
Japan
$116 +$116 +5 New
BC
130
Boxer Capital
California
– -$20.5M -696,480 Closed
ACA
131
Avoro Capital Advisors
New York
– -$17.6M -598,600 Closed
Walleye Capital
132
Walleye Capital
New York
– -$7.16M -243,372 Closed
Balyasny Asset Management
133
Balyasny Asset Management
Illinois
– -$6.7M -227,950 Closed
SSA
134
Schonfeld Strategic Advisors
New York
– -$1.35M -46,072 Closed
SCM
135
Superstring Capital Management
New York
– -$1.1M -37,287 Closed
AQR Capital Management
136
AQR Capital Management
Connecticut
– -$1.03M -35,003 Closed
Tudor Investment Corp
137
Tudor Investment Corp
Connecticut
– -$916K -31,138 Closed
Jane Street
138
Jane Street
New York
– -$607K -20,641 Closed
SG Americas Securities
139
SG Americas Securities
New York
– -$370K -12,589 Closed
ACM
140
ADAR1 Capital Management
Texas
– -$369K -12,560 Closed
Acadian Asset Management
141
Acadian Asset Management
Massachusetts
– -$23K -814 Closed
NC
142
nVerses Capital
Florida
– -$14.7K -500 Closed
Russell Investments Group
143
Russell Investments Group
United Kingdom
– -$3.79K -129 Closed
CPA
144
Capital Performance Advisors
California
– -$1.35K -46 Closed
Bessemer Group
145
Bessemer Group
New Jersey
– -$1K -45 Closed
LC
146
Lindbrook Capital
California
– -$559 -19 Closed
TWD
147
True Wealth Design
Ohio
– -$471 -16 Closed
US Bancorp
148
US Bancorp
Minnesota
– -$265 -9 Closed
GI
149
GAMMA Investing
California
– -$147 -5 Closed
National Bank of Canada
150
National Bank of Canada
Quebec, Canada
– -$29 -1 Closed
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