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Spyre Therapeutics
SYRE

Overview Fund Activity

129 hedge funds and large institutions have $1B invested in Spyre Therapeutics in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 52 increasing their positions, 35 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
-2
Holders Change %
-1.53%
% of All Funds
1.75%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
20
Increased
52
Reduced
35
Closed
21
Calls
$827K
Puts
$1.01M
Net Calls
-$182K
Net Calls Change
-$264K

Top Buyers

1
Capital International Investors
Capital International Investors
California
+$38.6M
2
TCM
Tang Capital Management
California
+$33.1M
3
PBA
Paradigm Biocapital Advisors
New York
+$9.68M
4
Bank of America
Bank of America
North Carolina
+$6.78M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$3.83M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$15.3M
2
LGM
Logos Global Management
California
-$11.6M
3
BCM
Boxer Capital Management
California
-$10.9M
4
Goldman Sachs
Goldman Sachs
New York
-$8.88M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$7.45M
Name Holding Trade Value Shares
Change 		Shares
Change %
Mirae Asset Global Investments
101
Mirae Asset Global Investments
South Korea
$36.2K +$1.09K +61 +3%
Royal Bank of Canada
102
Royal Bank of Canada
Ontario, Canada
$35K -$29.8K -1,850 -46%
TRCT
103
Tower Research Capital (TRC)
New York
$33K -$105K -6,530 -76%
Public Employees Retirement Association of Colorado
104
Public Employees Retirement Association of Colorado
Colorado
$26K – – –
GFM
105
GF Fund Management
China
$24.2K +$4.36K +270 +22%
HNB
106
Huntington National Bank
Ohio
$23.7K – – –
AB
107
Amalgamated Bank
New York
$22K +$2.89K +181 +15%
SCM
108
Sterling Capital Management
North Carolina
$10.1K -$6.13K -380 -38%
Carson Wealth (CWM LLC)
109
Carson Wealth (CWM LLC)
Nebraska
$6K +$5.87K +366 +4,575%
GI
110
GAMMA Investing
California
$4.36K +$4.36K +270 New
Osaic Holdings
111
Osaic Holdings
Arizona
$3.84K +$2.15K +133 +127%
Daiwa Securities Group
112
Daiwa Securities Group
Japan
$3K +$3K +206 New
Nisa Investment Advisors
113
Nisa Investment Advisors
Missouri
$2.97K +$1.03K +64 +53%
ACM
114
Aster Capital Management
United Arab Emirates
$2.48K +$2.48K +126 New
SSG
115
Summit Securities Group
New York
$2.15K +$2.15K +133 New
IA
116
IFP Advisors
Florida
$1.92K – – –
LC
117
Lindbrook Capital
California
$1.26K +$1.26K +78 New
RIL
118
Rothschild Investment LLC
Illinois
$807 +$161 +10 +25%
LFG
119
Larson Financial Group
Missouri
$710 +$710 +44 New
CA
120
CoreCap Advisors
Michigan
$662 +$662 +41 New
CIAM
121
Caitong International Asset Management
Hong Kong
$452 +$226 +14 +100%
EWA
122
EverSource Wealth Advisors
Alabama
$387 +$258 +16 +200%
SC
123
Stephens Consulting
Michigan
$323 +$323 +20 New
PA
124
Parallel Advisors
California
$226 +$226 +14 New
AF
125
Allworth Financial
California
$195 +$60 +4 +44%
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