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Spyre Therapeutics
SYRE

Overview Fund Activity

103 hedge funds and large institutions have $1.21B invested in Spyre Therapeutics in 2024 Q1 according to their latest regulatory filings, with 55 funds opening new positions, 20 increasing their positions, 15 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
103
Holders Change
+49
Holders Change %
+90.74%
% of All Funds
1.49%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.07%
New
55
Increased
20
Reduced
15
Closed
6
Calls
$76K
Puts
–
Net Calls
+$76K
Net Calls Change
+$32K

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$105M
2
BlackRock
BlackRock
New York
+$20.4M
3
DGM
Darwin Global Management
Jersey
+$17.9M
4
FCM
Farallon Capital Management
California
+$17.7M
5
FTM
First Turn Management
California
+$17.6M

Top Sellers

1
DTC
Deep Track Capital
Connecticut
-$28M
2
CAM
Cormorant Asset Management
Massachusetts
-$26.1M
3
EC
EcoR1 Capital
California
-$19.1M
4
GEM
Global Endowment Management
North Carolina
-$18.8M
5
HS
HighVista Strategies
Massachusetts
-$16.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
BC
26
Boxer Capital
California
$9.48M – – –
LGM
27
Logos Global Management
California
$9.48M +$3.79M +100,000 +67%
Goldman Sachs
28
Goldman Sachs
New York
$9.1M +$9.1M +239,915 New
Voloridge Investment Management
29
Voloridge Investment Management
Florida
$7.13M +$7.13M +188,053 New
SCM
30
Suvretta Capital Management
New York
$6.16M – – –
Marshall Wace
31
Marshall Wace
United Kingdom
$6.14M +$5.37M +141,669 +700%
HS
32
HighVista Strategies
Massachusetts
$5.86M -$16.1M -423,235 -73%
Invesco
33
Invesco
Georgia
$5.79M +$5.79M +152,578 New
State Street
34
State Street
Massachusetts
$5.1M +$5.1M +134,426 New
GPP
35
Great Point Partners
Connecticut
$4.74M – – –
Walleye Capital
36
Walleye Capital
New York
$4.23M +$4.23M +111,478 New
CS
37
Candriam SCA
Luxembourg
$3.98M +$3.98M +105,000 New
Susquehanna International Group
38
Susquehanna International Group
Pennsylvania
$3.85M +$3.85M +101,503 New
WP
39
Woodline Partners
California
$3.81M +$3.81M +100,527 New
GTC
40
Ghost Tree Capital
New York
$3.79M +$3.79M +100,000 New
IHAM
41
Integral Health Asset Management
New York
$3.79M +$3.79M +100,000 New
NIP
42
Nicholas Investment Partners
California
$3.41M +$3.41M +89,962 New
HF
43
HRT Financial
New York
$3M +$3M +78,996 New
T. Rowe Price Associates
44
T. Rowe Price Associates
Maryland
$2.98M +$2.98M +78,529 New
Northern Trust
45
Northern Trust
Illinois
$2.52M +$2.52M +66,340 New
Assenagon Asset Management
46
Assenagon Asset Management
Luxembourg
$2.44M +$2.44M +64,400 New
SC
47
Stempoint Capital
New York
$2.36M -$12M -316,513 -84%
TD Asset Management
48
TD Asset Management
Ontario, Canada
$2.31M +$2.31M +60,968 New
Qube Research & Technologies (QRT)
49
Qube Research & Technologies (QRT)
United Kingdom
$2.19M +$2.19M +57,678 New
Morgan Stanley
50
Morgan Stanley
New York
$1.94M +$1.94M +51,108 +63,885%
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