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Spyre Therapeutics
SYRE

Overview Fund Activity

83 hedge funds and large institutions have $95.4M invested in Spyre Therapeutics in 2022 Q1 according to their latest regulatory filings, with 10 funds opening new positions, 28 increasing their positions, 26 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
83
Holders Change
-2
Holders Change %
-2.35%
% of All Funds
1.31%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
10
Increased
28
Reduced
26
Closed
12
Calls
$3K
Puts
–
Net Calls
+$3K
Net Calls Change
-$12K

Top Buyers

1
SCM
1
Suvretta Capital Management
New York
$9.34M
2
GTC
2
Ghost Tree Capital
New York
$1.58M
3
Deutsche Bank
3
Deutsche Bank
Germany
$1.19M
4
NCM
4
Nantahala Capital Management
Connecticut
$7.36M
5
SCM
5
Sio Capital Management
New York
$2M

Top Sellers

1
AG
1
Artal Group
Luxembourg
$0
2
Adage Capital Partners
2
Adage Capital Partners
Massachusetts
$0
3
GPP
3
Great Point Partners
Connecticut
$0
4
Axa
4
Axa
France
$0
5
ACM
5
Altium Capital Management
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
UOTTAIMCU
26
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$565K – – –
A
27
Abingworth
United Kingdom
$553K – – –
Two Sigma Investments
28
Two Sigma Investments
New York
$498K +$350K +6,084 +236%
Nuveen Asset Management
29
Nuveen Asset Management
Illinois
$425K +$754 +12 +0.2%
CAM
30
ClariVest Asset Management
California
$424K +$21.2K +368 +5%
Morgan Stanley
31
Morgan Stanley
New York
$418K -$33.4K -581 -7%
PPA
32
Parametric Portfolio Associates
Washington
$409K +$313K +5,442 +324%
Two Sigma Advisers
33
Two Sigma Advisers
New York
$371K +$283K +4,924 +322%
Bank of New York Mellon
34
Bank of New York Mellon
New York
$362K -$3.73K -65 -1%
Marshall Wace
35
Marshall Wace
United Kingdom
$355K +$259K +4,502 +270%
Renaissance Technologies
36
Renaissance Technologies
New York
$349K -$221K -3,853 -39%
Acadian Asset Management
37
Acadian Asset Management
Massachusetts
$342K +$42.5K +743 +14%
Walleye Capital
38
Walleye Capital
New York
$312K +$312K +5,424 New
BCM
39
Bridgeway Capital Management
Texas
$283K +$283K +4,920 New
YF
40
Yu Fan
$258K – – –
Charles Schwab
41
Charles Schwab
California
$246K +$16.9K +293 +7%
FSA
42
Franklin Street Advisors
North Carolina
$243K – – –
RWM
43
Ritholtz Wealth Management
New York
$176K – – –
William Blair & Company
44
William Blair & Company
Illinois
$176K – – –
Citadel Advisors
45
Citadel Advisors
Florida
$169K +$169K +2,937 New
UBS Group
46
UBS Group
Switzerland
$150K -$164K -2,854 -52%
AG
47
Algert Global
California
$131K +$56.4K +981 +76%
AA
48
ALPS Advisors
Colorado
$117K -$14.6K -254 -11%
RhumbLine Advisers
49
RhumbLine Advisers
Massachusetts
$113K -$11.5K -200 -9%
Franklin Resources
50
Franklin Resources
California
$106K +$106K +1,852 New
1
2
3 4