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Spyre Therapeutics
SYRE

Overview Fund Activity

85 hedge funds and large institutions have $189M invested in Spyre Therapeutics in 2021 Q4 according to their latest regulatory filings, with 18 funds opening new positions, 26 increasing their positions, 22 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
85
Holders Change
+8
Holders Change %
+10.39%
% of All Funds
1.31%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.03%
New
18
Increased
26
Reduced
22
Closed
9
Calls
$263K
Puts
$248K
Net Calls
+$15K
Net Calls Change
-$75K

Top Buyers

1
NCM
1
Nantahala Capital Management
Connecticut
$13.4M
2
LCM
2
Laurion Capital Management
New York
$6.89M
3
SCM
3
Suvretta Capital Management
New York
$12.2M
4
D.E. Shaw & Co
4
D.E. Shaw & Co
New York
$1.08M
5
CAM
5
ClariVest Asset Management
California
$832K

Top Sellers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$4.75M
2
O
2
OrbiMed
New York
$14M
3
Millennium Management
3
Millennium Management
New York
$905K
4
ACM
4
Altium Capital Management
New York
$1.4M
5
Marshall Wace
5
Marshall Wace
United Kingdom
$197K
Name Holding Trade Value Shares
Change 		Shares
Change %
Renaissance Technologies
26
Renaissance Technologies
New York
$1.18M +$703K +5,916 +147%
UOTTAIMCU
27
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$1.17M – – –
A
28
Abingworth
United Kingdom
$1.14M – – –
D.E. Shaw & Co
29
D.E. Shaw & Co
New York
$1.08M +$946K +7,960 +698%
Morgan Stanley
30
Morgan Stanley
New York
$932K +$9.5K +80 +1%
Millennium Management
31
Millennium Management
New York
$905K -$1.64M -13,790 -64%
CAM
32
ClariVest Asset Management
California
$832K +$832K +6,997 New
Bank of New York Mellon
33
Bank of New York Mellon
New York
$757K -$1.07K -9 -0.1%
Jacobs Levy Equity Management
34
Jacobs Levy Equity Management
New Jersey
$684K +$684K +5,764 New
Nuveen Asset Management
35
Nuveen Asset Management
Illinois
$653K -$41.9K -433 -6%
UBS Group
36
UBS Group
Switzerland
$649K +$391K +3,296 +152%
Acadian Asset Management
37
Acadian Asset Management
Massachusetts
$620K +$620K +5,233 New
YF
38
Yu Fan
$532K – – –
FSA
39
Franklin Street Advisors
North Carolina
$503K +$10.5K +88 +2%
Charles Schwab
40
Charles Schwab
California
$473K – – –
William Blair & Company
41
William Blair & Company
Illinois
$364K +$116K +976 +47%
RWM
42
Ritholtz Wealth Management
New York
$363K – – –
Two Sigma Investments
43
Two Sigma Investments
New York
$306K +$306K +2,580 New
AA
44
ALPS Advisors
Colorado
$271K +$271K +2,283 New
CSS
45
Cubist Systematic Strategies
Connecticut
$266K +$266K +2,238 New
RhumbLine Advisers
46
RhumbLine Advisers
Massachusetts
$256K -$1.07K -9 -0.4%
Barclays
47
Barclays
United Kingdom
$233K +$155K +1,305 +197%
PPA
48
Parametric Portfolio Associates
Washington
$199K -$14.8K -125 -7%
Marshall Wace
49
Marshall Wace
United Kingdom
$197K -$1.3M -10,968 -87%
Two Sigma Advisers
50
Two Sigma Advisers
New York
$181K +$181K +1,528 New
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