ALPS Medical Breakthroughs ETF
SBIO
59 hedge funds and large institutions have $79.2M invested in ALPS Medical Breakthroughs ETF in 2025 Q4 according to their latest regulatory filings, with 26 funds opening new positions, 14 increasing their positions, 8 reducing their positions, and 6 closing their positions.
333% more first-time investments, than exits
New positions opened: 26 | Existing positions closed: 6
75% more repeat investments, than reductions
Existing positions increased: 14 | Existing positions reduced: 8
48% more funds holding
Funds holding: 40 → 59 (+19)
6% more capital invested
Capital invested by funds: $74.7M → $79.2M (+$4.53M)
10.54% less ownership
Funds ownership: 102.96% → 92.42% (-11%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DIM
Delta Investment Management
San Francisco,
California
|
+$5.52M |
| 2 |
Raymond James Financial
St Petersburg,
Florida
|
+$4.44M |
| 3 |
LPL Financial
San Diego,
California
|
+$1.61M |
| 4 |
Two Sigma Investments
New York
|
+$1.53M |
| 5 |
Stifel Financial
St. Louis,
Missouri
|
+$919K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DC
Davenport & Co
Richmond,
Virginia
|
-$21.9M |
| 2 |
Wells Fargo
San Francisco,
California
|
-$4.58M |
| 3 |
GS
GTS Securities
Miami,
Florida
|
-$1.49M |
| 4 |
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
-$306K |
| 5 |
SFS
Strategic Financial Services
Utica,
New York
|
-$208K |
SBIO Hedge Fund Activity: Q4 2025 in Review
59 of the 8,267 institutional investors tracked by Wall St. Rank reported a position in ALPS Medical Breakthroughs ETF (SBIO) for Q4 2025, worth a combined $79.2M — up 6.1% from $74.7M a quarter earlier.
Buyers outnumbered sellers: 26 funds opened new SBIO positions and 6 closed out — a net gain of 20 holders — while 14 added to existing stakes and 8 trimmed.
The largest buyer was Delta Investment Management, opening a new position worth an estimated $5.52M. The largest seller was Davenport & Co, cutting an estimated $21.9M.
- 59 institutional investors held ALPS Medical Breakthroughs ETF (SBIO) as of Q4 2025, up from 40 in Q3 2025.
- Funds reported $79.2M of ALPS Medical Breakthroughs ETF stock for Q4 2025, up 6.1% quarter-over-quarter.
- 26 funds opened new ALPS Medical Breakthroughs ETF positions in Q4 2025 and 6 closed out, a net change of +20 holders.
- The largest ALPS Medical Breakthroughs ETF buyer in Q4 2025 was Delta Investment Management, an estimated $5.52M added.
- The largest ALPS Medical Breakthroughs ETF seller in Q4 2025 was Davenport & Co, an estimated $21.9M sold.
Based on aggregated 13F filings for Q4 2025.