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ALPS Medical Breakthroughs ETF
SBIO

34 hedge funds and large institutions have $73M invested in ALPS Medical Breakthroughs ETF in 2025 Q1 according to their latest regulatory filings, with 5 funds opening new positions, 4 increasing their positions, 13 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed

467% more call options, than puts

Call options by funds: $34K | Put options by funds: $6K

50.99% more ownership

Funds ownership: 47.46% → 98.45% (+51%)

49% more capital invested

Capital invested by funds: $49.1M → $73M (+$23.9M)

3% less funds holding

Funds holding: 35 → 34 (-1)

17% less first-time investments, than exits

New positions opened: 5 | Existing positions closed: 6

69% less repeat investments, than reductions

Existing positions increased: 4 | Existing positions reduced: 13

Holders
34
Holders Change
-1
Holders Change %
-2.86%
% of All Funds
0.46%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
5
Increased
4
Reduced
13
Closed
6
Calls
$34K
Puts
$6K
Net Calls
+$28K
Net Calls Change
+$2K

Top Buyers

Rank Fund Capital Flow
1
PF
Phoenix Financial
Israel
+$46.3M
2
GS
GWN Securities
Florida
+$1.75M
3
Bank of America
Bank of America
North Carolina
+$236K
4
RF
Rossby Financial
Florida
+$164K
5
SFS
Strategic Financial Services
New York
+$68.4K

Top Sellers

Rank Fund Capital Flow
1
Morgan Stanley
Morgan Stanley
New York
-$1.01M
2
DC
Davenport & Co
Virginia
-$675K
3
Susquehanna International Group
Susquehanna International Group
Pennsylvania
-$565K
4
GS
GTS Securities
New York
-$537K
5
UBS Group
UBS Group
Switzerland
-$445K
Name Holding Trade Value Shares
Change 		Change in
Stake
IA
26
IFP Advisors
Florida
$9.46K +$10.5K +332 New
S
27
SignatureFD
Georgia
$5.7K – – –
ADL
28
Asset Dedication LLC
California
$4.76K – – –
SC
29
SouthState Corp
Florida
$3.99K – – –
Bank of Montreal
30
Bank of Montreal
Ontario, Canada
$2.85K – – –
FCAS
31
First Command Advisory Services
Texas
$2.85K – – –
SL
32
Salomon & Ludwin
Virginia
$2.85K – – –
AFG
33
Albion Financial Group
Utah
$343 – – –
Susquehanna International Group
34
Susquehanna International Group
Pennsylvania
– -$565K -17,115 Closed
MML Investors Services
35
MML Investors Services
Massachusetts
– -$313K -9,487 Closed
Jane Street
36
Jane Street
New York
– -$246K -7,444 Closed
RPCONE
37
Retirement Planning Company of New England
Rhode Island
– -$228K -6,894 Closed
TRCT
38
Tower Research Capital (TRC)
New York
– -$3.3K -100 Closed
MPWT
39
MassMutual Private Wealth & Trust
Connecticut
– -$2.91K -88 Closed
Carson Wealth (CWM LLC)
40
Carson Wealth (CWM LLC)
Nebraska
– +$474 +15 New
1
2

SBIO Hedge Fund Activity: Q1 2025 in Review

34 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in ALPS Medical Breakthroughs ETF (SBIO) for Q1 2025, worth a combined $73M — up 49% from $49.1M a quarter earlier.

Sellers outnumbered buyers: 6 funds closed out of SBIO and 5 opened new positions — a net loss of 1 holder — while 13 trimmed existing stakes and 4 added.

The largest buyer was Phoenix Financial, opening a new position worth an estimated $46.3M. The largest seller was Morgan Stanley, cutting an estimated $1.01M.

  • 34 institutional investors held ALPS Medical Breakthroughs ETF (SBIO) as of Q1 2025, down from 35 in Q4 2024.
  • Funds reported $73M of ALPS Medical Breakthroughs ETF stock for Q1 2025, up 49% quarter-over-quarter.
  • 5 funds opened new ALPS Medical Breakthroughs ETF positions in Q1 2025 and 6 closed out, a net change of -1 holder.
  • The largest ALPS Medical Breakthroughs ETF buyer in Q1 2025 was Phoenix Financial, an estimated $46.3M added.
  • The largest ALPS Medical Breakthroughs ETF seller in Q1 2025 was Morgan Stanley, an estimated $1.01M sold.

Based on aggregated 13F filings for Q1 2025.