ALPS Medical Breakthroughs ETF

SBIO

Market cap $200M

Big Pharma has a $300 billion problem, and biotech developers with promising drugs are becoming the fix. Major drugmakers are spending at a pace not seen since 2019 to replace medicines that will soon lose patent protection.

Designed to provide broad exposure to the Healthcare - Broad segment of the equity market, the ALPS Medical Breakthroughs ETF (SBIO) is a passively managed exchange traded fund launched on December 31, 2014.

ALPS Medical Breakthroughs ETF targets late-stage clinical trial biotechs primed for outsized performance and M&A. SBIO's selective criteria focus on U.S.-listed firms with strong cash positions, Phase 2/3 assets, and near-term catalysts, creating a portfolio of high-volatility, high-alpha 'lottery tickets.' SBIO has delivered 111% returns over the past year, outperforming the S&P 500; its holdings have seen notable buyouts and clinical milestones.

Biotech stocks delivered their best single month since late 2023 in June, carrying the ALPS Medical Breakthroughs ETF (SBIO) to one of the top returns across the ALPS lineup. Key Takeaways: SBIO returned 18.7% in June, its best single month since December 2023.

June has been a month full of excitement in the ETF market. While commercial space and AI infrastructure attracted a significant amount of investor attention, biotechnology exposure comprises four out of the five top-performing equity ETFs as of June 29.

After a sweeping semi-annual rebalance, the biotech index underlying the ALPS Medical Breakthroughs ETF (SBIO) gained over 10% in just six trading days beginning June 18. Key Takeaways: SBIO's underlying index gained 10.01% in six trading days following its June 18 semi-annual rebalance.

The biotechnology sector has broken out of its multiyear bear market. As macroeconomic headwinds moderate and regulatory environments stabilize, biotech ETFs are surging.

NichLmao, Peet Montzingo, DangMattSmith, Merrick Hanna and more to compete in a 16-player tournament produced by Creator TV®, set to premiere on streaming this summer. LOS ANGELES, June 15, 2026 /PRNewswire/ --  Creator TV® , the creator-led streaming network and content studio under Los Angeles-based Sabio Holdings (TSXV: SBIO) (OTCQB: SABOF ) (the "Company" or "Sabio"), revealed the first wave of the creator lineup for the inaugural Creator Pickleball Tour, in partnership with Rob Ryan.

With AI and space dominating many of the market's most popular investment themes, it can be difficult to find differentiated opportunities. Healthcare is often viewed as one of the more defensive sectors, supported by relatively steady demand regardless of the economic environment.

Sabio Holdings Inc. (SBIO:CA) Q1 2026 Earnings Call Transcript