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Spero Therapeutics

56 hedge funds and large institutions have $49.2M invested in Spero Therapeutics in 2025 Q4 according to their latest regulatory filings, with 16 funds opening new positions, 14 increasing their positions, 12 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding

Funds holding:

more ownership

Funds ownership:

17% more repeat investments, than reductions

Existing positions increased: 14 | Existing positions reduced: 12

14% less call options, than puts

Call options by funds: $263K | Put options by funds: $306K

Holders
56
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$263K
Puts
$306K
Net Calls
Net Calls Change

Top Buyers

1 +$924K
2 +$750K
3 +$682K
4
Two Sigma Advisers
Two Sigma Advisers
New York
+$503K
5
SEI Investments
SEI Investments
Pennsylvania
+$307K

Top Sellers

1 -$2.27M
2 -$402K
3 -$283K
4
EI
EAM Investors
California
-$149K
5
Morgan Stanley
Morgan Stanley
New York
-$100K