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Spero Therapeutics
SPRO

Overview Fund Activity

79 hedge funds and large institutions have $15.5M invested in Spero Therapeutics in 2022 Q2 according to their latest regulatory filings, with 16 funds opening new positions, 20 increasing their positions, 22 reducing their positions, and 35 closing their positions.

Holders
79
Holders Change
-21
Holders Change %
-21%
% of All Funds
1.34%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.02%
New
16
Increased
20
Reduced
22
Closed
35
Calls
$36K
Puts
$34K
Net Calls
+$2K
Net Calls Change
-$202K

Top Buyers

1
BI
1
BVF Inc
California
$2.29M
2
Renaissance Technologies
2
Renaissance Technologies
New York
$696K
3
D.E. Shaw & Co
3
D.E. Shaw & Co
New York
$481K
4
Two Sigma Investments
4
Two Sigma Investments
New York
$324K
5
OMC
5
Oasis Management Company
Cayman Islands
$213K

Top Sellers

1
Ameriprise
1
Ameriprise
Minnesota
$0
2
AIC
2
AWM Investment Company
New York
$0
3
Royal Bank of Canada
3
Royal Bank of Canada
Ontario, Canada
$0
4
GIM
4
Granahan Investment Management
Massachusetts
$0
5
BlackRock
5
BlackRock
New York
$513K
Name Market Value Shares Shares
Change 		Shares
Change %
ACM
1
Aquilo Capital Management
California
$3.94M 5,321,231 +39,727 +0.8%
BI
2
BVF Inc
California
$2.29M 3,089,615 +1,504,000 +95%
AVAI
3
Atlas Venture Associates IX
Massachusetts
$1.02M 1,376,968 – –
Vanguard Group
4
Vanguard Group
Pennsylvania
$924K 1,245,992 -127,936 -9%
AVLSA
5
Atlas Venture Life Science Advisors
Massachusetts
$764K 1,031,160 – –
Renaissance Technologies
6
Renaissance Technologies
New York
$696K 939,017 +829,917 +761%
AI
7
Alphabet Inc
California
$659K 889,979 – –
RSCM
8
Rock Springs Capital Management
Maryland
$571K 770,710 -220,203 -22%
BlackRock
9
BlackRock
New York
$513K 690,753 -1,103,328 -61%
D.E. Shaw & Co
10
D.E. Shaw & Co
New York
$481K 649,334 +630,688 +3,382%
AG
11
Artal Group
Luxembourg
$371K 500,000 – –
NHAS
12
Novo Holdings A/S
Denmark
$347K 468,902 – –
Two Sigma Investments
13
Two Sigma Investments
New York
$324K 437,280 +358,372 +454%
Millennium Management
14
Millennium Management
New York
$233K 314,643 +253,382 +414%
Goldman Sachs
15
Goldman Sachs
New York
$225K 303,201 +161,775 +114%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$215K 290,258 -180,931 -38%
OMC
17
Oasis Management Company
Cayman Islands
$213K 288,000 +288,000 New
Dimensional Fund Advisors
18
Dimensional Fund Advisors
Texas
$212K 284,956 -121,990 -30%
OMC
19
OUP Management Company
Pennsylvania
$185K 249,070 – –
Morgan Stanley
20
Morgan Stanley
New York
$144K 194,431 +121,435 +166%
Two Sigma Advisers
21
Two Sigma Advisers
New York
$131K 176,157 +159,757 +974%
AQR Capital Management
22
AQR Capital Management
Connecticut
$115K 155,474 +155,474 New
Assenagon Asset Management
23
Assenagon Asset Management
Luxembourg
$97K 131,020 +107,897 +467%
Citadel Advisors
24
Citadel Advisors
Florida
$80K 108,351 +97,554 +904%
E
25
Ergoteles
New York
$76K 102,408 +102,408 New
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