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Spero Therapeutics
SPRO

Overview Fund Activity

39 hedge funds and large institutions have $10.9M invested in Spero Therapeutics in 2025 Q1 according to their latest regulatory filings, with 2 funds opening new positions, 9 increasing their positions, 10 reducing their positions, and 12 closing their positions.

Holders
39
Holders Change
-11
Holders Change %
-22%
% of All Funds
0.53%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
2
Increased
9
Reduced
10
Closed
12
Calls
$7K
Puts
$2K
Net Calls
+$5K
Net Calls Change
+$5K

Top Buyers

1
Geode Capital Management
1
Geode Capital Management
Massachusetts
$378K
2
Squarepoint
2
Squarepoint
New York
$66.9K
3
Mackenzie Financial
3
Mackenzie Financial
Ontario, Canada
$151K
4
EWA
4
EP Wealth Advisors
California
$11.9K
5
Northern Trust
5
Northern Trust
Illinois
$72.7K

Top Sellers

1
Acadian Asset Management
1
Acadian Asset Management
Massachusetts
$626K
2
Renaissance Technologies
2
Renaissance Technologies
New York
$699K
3
Citadel Advisors
3
Citadel Advisors
Florida
$44.1K
4
Jane Street
4
Jane Street
New York
$0
5
VF
5
Virtu Financial
New York
$0
Name Market Value Shares Shares
Change 		Shares
Change %
AFM
1
Anson Funds Management
Texas
$2.74M 3,798,932 -40,954 -1%
P
2
Pfizer
New York
$1.7M 2,362,348 – –
Vanguard Group
3
Vanguard Group
Pennsylvania
$1.27M 1,763,620 – –
Renaissance Technologies
4
Renaissance Technologies
New York
$699K 970,907 -134,684 -12%
AI
5
Alphabet Inc
California
$641K 889,979 – –
M
6
Murchinson
Ontario, Canada
$629K 873,910 – –
Acadian Asset Management
7
Acadian Asset Management
Massachusetts
$626K 871,212 -168,710 -16%
ACM
8
ADAR1 Capital Management
Texas
$577K 801,277 – –
Geode Capital Management
9
Geode Capital Management
Massachusetts
$378K 524,869 +43,741 +9%
BlackRock
10
BlackRock
New York
$347K 482,082 -3,270 -0.7%
MCM
11
Monimus Capital Management
New Jersey
$224K 310,908 – –
AVLSA
12
Atlas Venture Life Science Advisors
Massachusetts
$220K 305,255 – –
Mackenzie Financial
13
Mackenzie Financial
Ontario, Canada
$151K 209,031 +21,472 +11%
BCM
14
Bridgeway Capital Management
Texas
$111K 154,800 -30,000 -16%
State Street
15
State Street
Massachusetts
$107K 148,911 – –
DCM
16
DAFNA Capital Management
California
$90K 125,000 – –
Northern Trust
17
Northern Trust
Illinois
$72.7K 100,924 +14,477 +17%
Squarepoint
18
Squarepoint
New York
$66.9K 92,939 +37,888 +69%
Citadel Advisors
19
Citadel Advisors
Florida
$44.1K 61,316 -111,556 -65%
JPMorgan Chase & Co
20
JPMorgan Chase & Co
New York
$43.8K 60,817 -807 -1%
Prudential Financial
21
Prudential Financial
New Jersey
$40.3K 56,000 +6,800 +14%
TSW
22
Three Seasons Wealth
Utah
$21.6K 30,000 – –
DIM
23
DLK Investment Management
California
$21.5K 29,825 +870 +3%
Charles Schwab
24
Charles Schwab
California
$20.6K 28,565 – –
EWA
25
EP Wealth Advisors
California
$11.9K 16,500 +16,500 New
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