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Spero Therapeutics

50 hedge funds and large institutions have $16.1M invested in Spero Therapeutics in 2024 Q4 according to their latest regulatory filings, with 12 funds opening new positions, 13 increasing their positions, 9 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

50% more first-time investments, than exits

New positions opened: 12 | Existing positions closed: 8

44% more repeat investments, than reductions

Existing positions increased: 13 | Existing positions reduced: 9

9% more funds holding

Funds holding: 4650 (+4)

5.92% more ownership

Funds ownership: 22.84%28.76% (+5.9%)

2% less capital invested

Capital invested by funds: $16.5M → $16.1M (-$391K)

Holders
50
Holders Change
+4
Holders Change %
+8.7%
% of All Funds
0.66%
Holding in Top 10
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
12
Increased
13
Reduced
9
Closed
8
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
AFM
1
Anson Funds Management
Texas
$3.96M +$106K +89,436 +2%
P
2
Pfizer
New York
$2.43M +$2.81M +2,362,348 New
Vanguard Group
3
Vanguard Group
Pennsylvania
$1.82M
Renaissance Technologies
4
Renaissance Technologies
New York
$1.14M +$156K +130,938 +13%
Acadian Asset Management
5
Acadian Asset Management
Massachusetts
$1.07M -$38K -31,938 -3%
AI
6
Alphabet Inc
California
$917K
M
7
Murchinson
Ontario, Canada
$900K +$1.04M +873,910 New
ACM
8
ADAR1 Capital Management
Texas
$825K +$68.8K +57,818 +8%
BlackRock
9
BlackRock
New York
$500K +$633 +532 +0.1%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$496K -$70 -59 -0%
MCM
11
Monimus Capital Management
New Jersey
$320K +$370K +310,908 New
AVLSA
12
Atlas Venture Life Science Advisors
Massachusetts
$314K -$116K -97,630 -24%
Mackenzie Financial
13
Mackenzie Financial
Ontario, Canada
$193K +$185K +155,656 +488%
BCM
14
Bridgeway Capital Management
Texas
$190K
Citadel Advisors
15
Citadel Advisors
Florida
$178K +$109K +91,447 +112%
State Street
16
State Street
Massachusetts
$153K +$21.9K +18,400 +14%
DCM
17
DAFNA Capital Management
California
$129K
Northern Trust
18
Northern Trust
Illinois
$89K -$29.8K -25,050 -22%
JP Morgan Chase
19
JP Morgan Chase
New York
$63.5K +$73K +61,388 +26,012%
Squarepoint
20
Squarepoint
New York
$56.7K +$65.5K +55,051 New
Jane Street
21
Jane Street
New York
$54.5K +$62.9K +52,869 New
Prudential Financial
22
Prudential Financial
New Jersey
$50.7K +$58.5K +49,200 New
VF
23
Virtu Financial
New York
$47K +$54.8K +46,046 New
XT
24
XTX Topco
Cayman Islands
$31K +$35.8K +30,138 New
TSW
25
Three Seasons Wealth
Utah
$30.9K

SPRO Hedge Fund Activity: Q4 2024 in Review

50 of the 7,592 institutional investors tracked by Wall St. Rank reported a position in Spero Therapeutics (SPRO) for Q4 2024, worth a combined $16.1M — down 2.4% from $16.5M a quarter earlier.

Buyers outnumbered sellers: 12 funds opened new SPRO positions and 8 closed out — a net gain of 4 holders — while 13 added to existing stakes and 9 trimmed.

The largest buyer was Murchinson, opening a new position worth an estimated $1.04M. The largest seller was Novo Holdings A/S, exiting entirely with an estimated $628K sold.

  • 50 institutional investors held Spero Therapeutics (SPRO) as of Q4 2024, up from 46 in Q3 2024.
  • Funds reported $16.1M of Spero Therapeutics stock for Q4 2024, down 2.4% quarter-over-quarter.
  • 12 funds opened new Spero Therapeutics positions in Q4 2024 and 8 closed out, a net change of +4 holders.
  • The largest Spero Therapeutics buyer in Q4 2024 was Murchinson, an estimated $1.04M added.
  • The largest Spero Therapeutics seller in Q4 2024 was Novo Holdings A/S, an estimated $628K sold.

Based on aggregated 13F filings for Q4 2024.