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Spero Therapeutics
SPRO

Overview Fund Activity

84 hedge funds and large institutions have $316M invested in Spero Therapeutics in 2021 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 25 increasing their positions, 20 reducing their positions, and 13 closing their positions.

Holders
84
Holders Change
-3
Holders Change %
-3.45%
% of All Funds
1.3%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
10
Increased
25
Reduced
20
Closed
13
Calls
$1.1M
Puts
$711K
Net Calls
+$385K
Net Calls Change
-$410K

Top Buyers

1
AVLSA
1
Atlas Venture Life Science Advisors
Massachusetts
$16.5M
2
ACM
2
Aquilo Capital Management
California
$79.5M
3
OMC
3
OUP Management Company
Pennsylvania
$3.99M
4
Vanguard Group
4
Vanguard Group
Pennsylvania
$21.6M
5
Dimensional Fund Advisors
5
Dimensional Fund Advisors
Texas
$5.94M

Top Sellers

1
BI
1
BVF Inc
California
$25.4M
2
GIM
2
Granahan Investment Management
Massachusetts
$6.07M
3
BGIM
3
Brandywine Global Investment Management
Pennsylvania
$0
4
WJWM
4
Williams Jones Wealth Management
New York
$1.2M
5
CCIA
5
Campbell & Co Investment Adviser
Maryland
$0
Name Market Value Shares Shares
Change 		Shares
Change %
ACM
1
Aquilo Capital Management
California
$79.5M 4,964,181 +400,493 +9%
BlackRock
2
BlackRock
New York
$28.8M 1,798,777 -3,751 -0.2%
BI
3
BVF Inc
California
$25.4M 1,585,615 -223,737 -12%
AVAI
4
Atlas Venture Associates IX
Massachusetts
$22M 1,376,968 – –
Vanguard Group
5
Vanguard Group
Pennsylvania
$21.6M 1,351,378 +58,880 +5%
AVLSA
6
Atlas Venture Life Science Advisors
Massachusetts
$16.5M 1,031,160 +1,031,160 New
RSCM
7
Rock Springs Capital Management
Maryland
$15.1M 945,313 +3,770 +0.4%
AI
8
Alphabet Inc
California
$14.2M 889,979 – –
State Street
9
State Street
Massachusetts
$13.5M 843,955 +41,264 +5%
AG
10
Artal Group
Luxembourg
$8.01M 500,000 – –
NHAS
11
Novo Holdings A/S
Denmark
$7.51M 468,902 – –
Geode Capital Management
12
Geode Capital Management
Massachusetts
$7.32M 457,184 +12,270 +3%
GIM
13
Granahan Investment Management
Massachusetts
$6.07M 378,932 -176,682 -32%
AIC
14
AWM Investment Company
New York
$5.97M 372,755 – –
Dimensional Fund Advisors
15
Dimensional Fund Advisors
Texas
$5.94M 371,222 +41,589 +13%
Ameriprise
16
Ameriprise
Minnesota
$5.82M 363,534 -13,561 -4%
Northern Trust
17
Northern Trust
Illinois
$4.05M 253,200 -4,739 -2%
OMC
18
OUP Management Company
Pennsylvania
$3.99M 249,070 +249,070 New
Royal Bank of Canada
19
Royal Bank of Canada
Ontario, Canada
$2.92M 182,595 +2,493 +1%
Goldman Sachs
20
Goldman Sachs
New York
$2.22M 138,611 +1,032 +0.8%
JPMorgan Chase & Co
21
JPMorgan Chase & Co
New York
$1.56M 97,185 -7,749 -7%
Susquehanna International Group
22
Susquehanna International Group
Pennsylvania
$1.2M 75,183 +35,435 +89%
WJWM
23
Williams Jones Wealth Management
New York
$1.2M 75,000 -30,500 -29%
Bank of New York Mellon
24
Bank of New York Mellon
New York
$1.2M 75,000 +793 +1%
LBA
25
Letko, Brosseau & Associates
Quebec, Canada
$1.18M 73,659 – –
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