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Spero Therapeutics

84 hedge funds and large institutions have $316M invested in Spero Therapeutics in 2021 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 25 increasing their positions, 20 reducing their positions, and 13 closing their positions.

New
Increased
Maintained
Reduced
Closed

54% more call options, than puts

Call options by funds: $1.1M | Put options by funds: $711K

25% more repeat investments, than reductions

Existing positions increased: 25 | Existing positions reduced: 20

4.1% more ownership

Funds ownership: 57.14%61.24% (+4.1%)

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

3% less funds holding

Funds holding: 8784 (-3)

6% less capital invested

Capital invested by funds: $338M → $316M (-$21.8M)

23% less first-time investments, than exits

New positions opened: 10 | Existing positions closed: 13

Holders
84
Holders Change
-3
Holders Change %
-3.45%
% of All Funds
1.29%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
10
Increased
25
Reduced
20
Closed
13
Calls
$1.1M
Puts
$711K
Net Calls
+$385K
Net Calls Change
-$410K
Name Holding Trade Value Shares
Change
Change in
Stake
ACM
1
Aquilo Capital Management
California
$79.5M +$6.36M +400,493 +9%
BlackRock
2
BlackRock
New York
$28.8M -$59.6K -3,751 -0.2%
BI
3
BVF Inc
California
$25.4M -$3.55M -223,737 -12%
AVAI
4
Atlas Venture Associates IX
Massachusetts
$22M
Vanguard Group
5
Vanguard Group
Pennsylvania
$21.6M +$935K +58,880 +5%
AVLSA
6
Atlas Venture Life Science Advisors
Massachusetts
$16.5M +$16.4M +1,031,160 New
RSCM
7
Rock Springs Capital Management
Maryland
$15.1M +$59.9K +3,770 +0.4%
AI
8
Alphabet Inc
California
$14.2M
State Street
9
State Street
Massachusetts
$13.5M +$655K +41,264 +5%
AG
10
Artal Group
Luxembourg
$8.01M
NHAS
11
Novo Holdings A/S
Denmark
$7.51M
Geode Capital Management
12
Geode Capital Management
Massachusetts
$7.32M +$195K +12,270 +3%
GIM
13
Granahan Investment Management
Massachusetts
$6.07M -$2.81M -176,682 -32%
AIC
14
AWM Investment Company
New York
$5.97M
Dimensional Fund Advisors
15
Dimensional Fund Advisors
Texas
$5.94M +$661K +41,589 +13%
Ameriprise
16
Ameriprise
Minnesota
$5.82M -$215K -13,561 -4%
Northern Trust
17
Northern Trust
Illinois
$4.05M -$75.3K -4,739 -2%
OMC
18
OUP Management Company
Pennsylvania
$3.99M +$3.96M +249,070 New
Royal Bank of Canada
19
Royal Bank of Canada
Ontario, Canada
$2.92M +$39.6K +2,493 +1%
Goldman Sachs
20
Goldman Sachs
New York
$2.22M +$16.4K +1,032 +0.8%
JP Morgan Chase
21
JP Morgan Chase
New York
$1.56M -$123K -7,749 -7%
Susquehanna International Group
22
Susquehanna International Group
Pennsylvania
$1.2M +$563K +35,435 +89%
WJWM
23
Williams Jones Wealth Management
New York
$1.2M -$484K -30,500 -29%
Bank of New York Mellon
24
Bank of New York Mellon
New York
$1.2M +$12.6K +793 +1%
LBA
25
Letko, Brosseau & Associates
Quebec, Canada
$1.18M

SPRO Hedge Fund Activity: Q4 2021 in Review

84 of the 6,498 institutional investors tracked by Wall St. Rank reported a position in Spero Therapeutics (SPRO) for Q4 2021, worth a combined $316M — down 6.4% from $338M a quarter earlier.

Sellers outnumbered buyers: 13 funds closed out of SPRO and 10 opened new positions — a net loss of 3 holders — while 20 trimmed existing stakes and 25 added.

The largest buyer was Aquilo Capital Management, adding an estimated $6.36M. The largest seller was BVF Inc, cutting an estimated $3.55M.

  • 84 institutional investors held Spero Therapeutics (SPRO) as of Q4 2021, down from 87 in Q3 2021.
  • Funds reported $316M of Spero Therapeutics stock for Q4 2021, down 6.4% quarter-over-quarter.
  • 10 funds opened new Spero Therapeutics positions in Q4 2021 and 13 closed out, a net change of -3 holders.
  • The largest Spero Therapeutics buyer in Q4 2021 was Aquilo Capital Management, an estimated $6.36M added.
  • The largest Spero Therapeutics seller in Q4 2021 was BVF Inc, an estimated $3.55M sold.

Based on aggregated 13F filings for Q4 2021.