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Spero Therapeutics
SPRO

Overview Fund Activity

42 hedge funds and large institutions have $31.9M invested in Spero Therapeutics in 2025 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 9 increasing their positions, 9 reducing their positions, and 11 closing their positions.

Holders
42
Holders Change
+3
Holders Change %
+7.69%
% of All Funds
0.56%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
14
Increased
9
Reduced
9
Closed
11
Calls
$447K
Puts
$1.24M
Net Calls
-$794K
Net Calls Change
-$799K

Top Buyers

1
SSA
1
Schonfeld Strategic Advisors
New York
$1.48M
2
EI
2
EAM Investors
California
$694K
3
Vanguard Group
3
Vanguard Group
Pennsylvania
$5.66M
4
SCM
4
Stonepine Capital Management
Oregon
$455K
5
ICM
5
Ionic Capital Management
New York
$435K

Top Sellers

1
AFM
1
Anson Funds Management
Texas
$4.68M
2
Acadian Asset Management
2
Acadian Asset Management
Massachusetts
$327K
3
ACM
3
ADAR1 Capital Management
Texas
$417K
4
M
4
Murchinson
Ontario, Canada
$0
5
Renaissance Technologies
5
Renaissance Technologies
New York
$2.41M
Name Market Value Shares Shares
Change 		Shares
Change %
P
1
Pfizer
New York
$6.85M 2,362,348 – –
Vanguard Group
2
Vanguard Group
Pennsylvania
$5.66M 1,950,381 +186,761 +11%
AFM
3
Anson Funds Management
Texas
$4.68M 1,615,469 -2,183,463 -57%
AI
4
Alphabet Inc
California
$2.58M 889,979 – –
Renaissance Technologies
5
Renaissance Technologies
New York
$2.41M 832,165 -138,742 -14%
SSA
6
Schonfeld Strategic Advisors
New York
$1.48M 510,834 +510,834 New
Geode Capital Management
7
Geode Capital Management
Massachusetts
$1.48M 510,699 -14,170 -3%
BlackRock
8
BlackRock
New York
$1.26M 434,768 -47,314 -10%
MCM
9
Monimus Capital Management
New Jersey
$902K 310,908 – –
EI
10
EAM Investors
California
$694K 239,140 +239,140 New
SCM
11
Stonepine Capital Management
Oregon
$455K 156,888 +156,888 New
State Street
12
State Street
Massachusetts
$445K 153,451 +4,540 +3%
ICM
13
Ionic Capital Management
New York
$435K 150,000 +150,000 New
ACM
14
ADAR1 Capital Management
Texas
$417K 143,917 -657,360 -82%
BCM
15
Bridgeway Capital Management
Texas
$333K 114,800 -40,000 -26%
Acadian Asset Management
16
Acadian Asset Management
Massachusetts
$327K 112,889 -758,323 -87%
Citadel Advisors
17
Citadel Advisors
Florida
$301K 103,786 +42,470 +69%
Northern Trust
18
Northern Trust
Illinois
$292K 100,831 -93 -0.1%
XT
19
XTX Topco
Cayman Islands
$100K 34,551 +34,551 New
AWM
20
Axxcess Wealth Management
California
$94.4K 32,548 +32,548 New
CAAS
21
Capital Asset Advisory Services
Michigan
$94.4K 32,548 +32,548 New
QC
22
Quadrature Capital
United Kingdom
$90.5K 31,205 +31,205 New
TSW
23
Three Seasons Wealth
Utah
$87K 30,000 – –
Simplex Trading
24
Simplex Trading
Illinois
$87K 30,322 +25,224 +495%
Charles Schwab
25
Charles Schwab
California
$82.8K 28,565 – –
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