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Spero Therapeutics
SPRO

Overview Fund Activity

100 hedge funds and large institutions have $180M invested in Spero Therapeutics in 2022 Q1 according to their latest regulatory filings, with 25 funds opening new positions, 15 increasing their positions, 23 reducing their positions, and 8 closing their positions.

Holders
100
Holders Change
+16
Holders Change %
+19.05%
% of All Funds
1.58%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
25
Increased
15
Reduced
23
Closed
8
Calls
$219K
Puts
$15K
Net Calls
+$204K
Net Calls Change
-$181K

Top Buyers

1
ACM
1
Aquilo Capital Management
California
$45.9M
2
Ameriprise
2
Ameriprise
Minnesota
$5.1M
3
Renaissance Technologies
3
Renaissance Technologies
New York
$949K
4
Two Sigma Investments
4
Two Sigma Investments
New York
$686K
5
KCM
5
Knoll Capital Management
Florida
$609K

Top Sellers

1
State Street
1
State Street
Massachusetts
$4.33M
2
GIM
2
Granahan Investment Management
Massachusetts
$986K
3
Rafferty Asset Management
3
Rafferty Asset Management
New York
$0
4
IA
4
IndexIQ Advisors
New York
$0
5
WJWM
5
Williams Jones Wealth Management
New York
$226K
Name Market Value Shares Shares
Change 		Shares
Change %
ACM
1
Aquilo Capital Management
California
$45.9M 5,281,504 +317,323 +6%
BlackRock
2
BlackRock
New York
$15.6M 1,794,081 -4,696 -0.3%
BI
3
BVF Inc
California
$13.8M 1,585,615 – –
AVAI
4
Atlas Venture Associates IX
Massachusetts
$12M 1,376,968 – –
Vanguard Group
5
Vanguard Group
Pennsylvania
$12M 1,373,928 +22,550 +2%
AVLSA
6
Atlas Venture Life Science Advisors
Massachusetts
$8.97M 1,031,160 – –
RSCM
7
Rock Springs Capital Management
Maryland
$8.62M 990,913 +45,600 +5%
AI
8
Alphabet Inc
California
$7.74M 889,979 – –
Ameriprise
9
Ameriprise
Minnesota
$5.1M 586,642 +223,108 +61%
AG
10
Artal Group
Luxembourg
$4.35M 500,000 – –
State Street
11
State Street
Massachusetts
$4.33M 497,185 -346,770 -41%
Geode Capital Management
12
Geode Capital Management
Massachusetts
$4.1M 471,189 +14,005 +3%
NHAS
13
Novo Holdings A/S
Denmark
$4.08M 468,902 – –
Dimensional Fund Advisors
14
Dimensional Fund Advisors
Texas
$3.54M 406,946 +35,724 +10%
Osaic Holdings
15
Osaic Holdings
Arizona
$3.47M 1,095 -30 -3%
AIC
16
AWM Investment Company
New York
$3.24M 372,755 – –
OMC
17
OUP Management Company
Pennsylvania
$2.17M 249,070 – –
Northern Trust
18
Northern Trust
Illinois
$2.07M 238,452 -14,748 -6%
Royal Bank of Canada
19
Royal Bank of Canada
Ontario, Canada
$1.71M 196,097 +13,502 +7%
Goldman Sachs
20
Goldman Sachs
New York
$1.23M 141,426 +2,815 +2%
GIM
21
Granahan Investment Management
Massachusetts
$986K 113,322 -265,610 -70%
Renaissance Technologies
22
Renaissance Technologies
New York
$949K 109,100 +109,100 New
JPMorgan Chase & Co
23
JPMorgan Chase & Co
New York
$706K 81,172 -16,013 -16%
Two Sigma Investments
24
Two Sigma Investments
New York
$686K 78,908 +78,908 New
LBA
25
Letko, Brosseau & Associates
Quebec, Canada
$641K 73,659 – –
1
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