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Spero Therapeutics
SPRO

Overview Fund Activity

89 hedge funds and large institutions have $370M invested in Spero Therapeutics in 2020 Q4 according to their latest regulatory filings, with 24 funds opening new positions, 34 increasing their positions, 23 reducing their positions, and 13 closing their positions.

Holders
89
Holders Change
+11
Holders Change %
+14.1%
% of All Funds
1.58%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.05%
New
24
Increased
34
Reduced
23
Closed
13
Calls
$1.5M
Puts
$2.04M
Net Calls
-$539K
Net Calls Change
-$142K

Top Buyers

1
AVAX
1
Atlas Venture Associates XI
Massachusetts
$26.7M
2
BI
2
BVF Inc
California
$43.5M
3
BlackRock
3
BlackRock
New York
$33.6M
4
Ameriprise
4
Ameriprise
Minnesota
$5.15M
5
Morgan Stanley
5
Morgan Stanley
New York
$5.26M

Top Sellers

1
ACM
1
Aquilo Capital Management
California
$76.2M
2
NHAS
2
Novo Holdings A/S
Denmark
$11.2M
3
AI
3
Alphabet Inc
California
$17.3M
4
AIC
4
AWM Investment Company
New York
$7.23M
5
AG
5
Artal Group
Luxembourg
$9.7M
Name Market Value Shares Shares
Change 		Shares
Change %
ACM
1
Aquilo Capital Management
California
$76.2M 3,932,209 -564,933 -13%
BI
2
BVF Inc
California
$43.5M 2,243,278 +898,944 +67%
BlackRock
3
BlackRock
New York
$33.6M 1,731,600 +654,438 +61%
AVAI
4
Atlas Venture Associates IX
Massachusetts
$26.7M 1,376,968 – –
AVAX
5
Atlas Venture Associates XI
Massachusetts
$26.7M 1,376,968 +1,376,968 New
RSCM
6
Rock Springs Capital Management
Maryland
$23.9M 1,235,000 -1,256 -0.1%
Vanguard Group
7
Vanguard Group
Pennsylvania
$21.9M 1,130,730 +201,832 +22%
AI
8
Alphabet Inc
California
$17.3M 889,979 -222,494 -20%
NHAS
9
Novo Holdings A/S
Denmark
$11.2M 576,702 -354,397 -38%
AG
10
Artal Group
Luxembourg
$9.7M 500,000 -100,000 -17%
GIM
11
Granahan Investment Management
Massachusetts
$8.15M 420,320 +46,242 +12%
AIC
12
AWM Investment Company
New York
$7.23M 372,755 -126,000 -25%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$6.94M 358,148 +158,719 +80%
State Street
14
State Street
Massachusetts
$6.57M 338,831 +53,239 +19%
Morgan Stanley
15
Morgan Stanley
New York
$5.26M 271,258 +248,326 +1,083%
Northern Trust
16
Northern Trust
Illinois
$5.16M 265,973 +54,896 +26%
Ameriprise
17
Ameriprise
Minnesota
$5.15M 265,441 +265,441 New
Dimensional Fund Advisors
18
Dimensional Fund Advisors
Texas
$4.85M 250,197 +19,188 +8%
Assenagon Asset Management
19
Assenagon Asset Management
Luxembourg
$2.4M 123,785 +123,785 New
Nuveen Asset Management
20
Nuveen Asset Management
Illinois
$1.61M 82,946 +31,982 +63%
CCM
21
CAAS Capital Management
New York
$1.52M 78,509 +78,509 New
Susquehanna International Group
22
Susquehanna International Group
Pennsylvania
$1.44M 74,078 +16,670 +29%
JPMorgan Chase & Co
23
JPMorgan Chase & Co
New York
$1.43M 73,675 -16,213 -18%
Bank of New York Mellon
24
Bank of New York Mellon
New York
$1.36M 69,883 +18,357 +36%
LBA
25
Letko, Brosseau & Associates
Quebec, Canada
$1.32M 68,100 +68,100 New
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