Vanguard Group’s Spero Therapeutics SPRO Stock Holding History

Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake
Trade Value Portfolio Weight Portfolio Position
2025
Q4
$4.85M Buy
2,083,462
+93,607
+5% +$217K ﹤0.01% 3263
2025
Q3
$3.74M Buy
1,989,855
+39,474
+2% +$86.8K ﹤0.01% 3368
2025
Q2
$5.66M Buy
1,950,381
+186,761
+11% +$269K ﹤0.01% 3170
2025
Q1
$1.27M Hold
1,763,620
﹤0.01% 3638
2024
Q4
$1.82M Hold
1,763,620
﹤0.01% 3594
2024
Q3
$2.36M Sell
1,763,620
-6,905
-0.4% -$9.26K ﹤0.01% 3503
2024
Q2
$2.3M Buy
1,770,525
+117,093
+7% +$177K ﹤0.01% 3512
2024
Q1
$2.84M Buy
1,653,432
+9,675
+0.6% +$15.2K ﹤0.01% 3483
2023
Q4
$2.42M Buy
1,643,757
+86,161
+6% +$103K ﹤0.01% 3536
2023
Q3
$1.88M Buy
1,557,596
+31,122
+2% +$43.1K ﹤0.01% 3608
2023
Q2
$2.21M Buy
1,526,474
+99,903
+7% +$171K ﹤0.01% 3620
2023
Q1
$2.07M Buy
1,426,571
+372,183
+35% +$623K ﹤0.01% 3660
2022
Q4
$1.82M Buy
1,054,388
+665
+0.1% +$1.24K ﹤0.01% 3694
2022
Q3
$2.11M Sell
1,053,723
-192,269
-15% -$191K ﹤0.01% 3718
2022
Q2
$924K Sell
1,245,992
-127,936
-9% -$372K ﹤0.01% 4113
2022
Q1
$12M Buy
1,373,928
+22,550
+2% +$231K ﹤0.01% 3053
2021
Q4
$21.6M Buy
1,351,378
+58,880
+5% +$935K ﹤0.01% 2799
2021
Q3
$23.8M Buy
1,292,498
+15,708
+1% +$252K ﹤0.01% 2766
2021
Q2
$17.8M Buy
1,276,790
+170,094
+15% +$2.38M ﹤0.01% 2911
2021
Q1
$16.3M Sell
1,106,696
-24,034
-2% -$423K ﹤0.01% 2896
2020
Q4
$21.9M Buy
1,130,730
+201,832
+22% +$3.15M ﹤0.01% 2597
2020
Q3
$10.4M Buy
928,898
+193,664
+26% +$2.29M ﹤0.01% 2765
2020
Q2
$9.95M Buy
735,234
+106,646
+17% +$1.2M ﹤0.01% 2778
2020
Q1
$5.08M Buy
628,588
+132,187
+27% +$1.17M ﹤0.01% 2967
2019
Q4
$4.77M Sell
496,401
-286
-0.1% -$3.08K ﹤0.01% 3189
2019
Q3
$5.26M Buy
496,687
+59,483
+14% +$627K ﹤0.01% 3124
2019
Q2
$5.03M Buy
437,204
+18,814
+4% +$226K ﹤0.01% 3173
2019
Q1
$5.36M Buy
418,390
+255,826
+157% +$2.71M ﹤0.01% 3120
2018
Q4
$1M Sell
162,564
-292,852
-64% -$2.37M ﹤0.01% 3565
2018
Q3
$4.79M Buy
455,416
+330,580
+265% +$3.84M ﹤0.01% 3256
2018
Q2
$1.83M Buy
124,836
+13,797
+12% +$177K ﹤0.01% 3527
2018
Q1
$1.58M Buy
111,039
+65,550
+144% +$795K ﹤0.01% 3536
2017
Q4
$534K Buy
+45,489
New +$558K ﹤0.01% 3730

Other funds holding SPRO

Vanguard Group's SPRO Position: Q4 2025 in Review

Vanguard Group increased its Spero Therapeutics (SPRO) stake by 4.7% in Q4 2025, buying an estimated $217K and bringing the position to 2,083,462 shares worth $4.85M. The position accounts for ﹤0.01% of the portfolio, ranked #3263.

Vanguard Group first reported a position in SPRO in Q4 2017 and has held it in 33 quarters since. The position peaked at $23.8M in Q3 2021. 56 funds tracked by Wall St. Rank hold SPRO as of Q4 2025.

  • Vanguard Group held 2,083,462 shares of Spero Therapeutics worth $4.85M as of Q4 2025.
  • Vanguard Group bought 93,607 Spero Therapeutics shares in Q4 2025, an estimated $217K.
  • Spero Therapeutics made up ﹤0.01% of Vanguard Group's portfolio in Q4 2025, its #3263 holding.
  • Vanguard Group first reported a position in Spero Therapeutics in Q4 2017 and has held it in 33 quarters since.
  • Vanguard Group's Spero Therapeutics position peaked at $23.8M in Q3 2021.
  • 56 funds tracked by Wall St. Rank held Spero Therapeutics as of Q4 2025.

Based on Vanguard Group's 13F filing for Q4 2025, filed 29 Jan 2026.