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Spero Therapeutics
SPRO

Overview Fund Activity

39 hedge funds and large institutions have $10.9M invested in Spero Therapeutics in 2025 Q1 according to their latest regulatory filings, with 2 funds opening new positions, 9 increasing their positions, 10 reducing their positions, and 12 closing their positions.

Holders
39
Holders Change
-11
Holders Change %
-22%
% of All Funds
0.53%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
2
Increased
9
Reduced
10
Closed
12
Calls
$7K
Puts
$2K
Net Calls
+$5K
Net Calls Change
+$5K

Top Buyers

1
Geode Capital Management
1
Geode Capital Management
Massachusetts
$378K
2
Squarepoint
2
Squarepoint
New York
$66.9K
3
Mackenzie Financial
3
Mackenzie Financial
Ontario, Canada
$151K
4
EWA
4
EP Wealth Advisors
California
$11.9K
5
Northern Trust
5
Northern Trust
Illinois
$72.7K

Top Sellers

1
Acadian Asset Management
1
Acadian Asset Management
Massachusetts
$626K
2
Renaissance Technologies
2
Renaissance Technologies
New York
$699K
3
Citadel Advisors
3
Citadel Advisors
Florida
$44.1K
4
Jane Street
4
Jane Street
New York
$0
5
VF
5
Virtu Financial
New York
$0
Name Market Value Shares Shares
Change 		Shares
Change %
TYCC
26
Texas Yale Capital Corp
Florida
$7.2K 10,000 – –
Morgan Stanley
27
Morgan Stanley
New York
$5.02K 6,971 – –
Bank of America
28
Bank of America
North Carolina
$4.01K 5,565 +18 +0.3%
Fidelity Investments
29
Fidelity Investments
Massachusetts
$3.64K 5,056 +767 +18%
Simplex Trading
30
Simplex Trading
Illinois
$3K 5,098 -12 -0.2%
UBS Group
31
UBS Group
Switzerland
$2.04K 2,826 +2,685 +1,904%
CFB
32
Cullen/Frost Bankers
Texas
$1.44K 2,000 – –
BT
33
Banque Transatlantique
France
$266 400 +400 New
Wells Fargo
34
Wells Fargo
California
$144 200 – –
US Bancorp
35
US Bancorp
Minnesota
$109 151 -5,000 -97%
NA
36
NewEdge Advisors
Louisiana
$72 100 – –
SS
37
SBI Securities
Japan
$43 60 -153 -72%
CA
38
CoreCap Advisors
Michigan
$36 50 – –
BNP Paribas Financial Markets
39
BNP Paribas Financial Markets
France
$9 12 – –
Jane Street
40
Jane Street
New York
– – -52,869 Closed
VF
41
Virtu Financial
New York
– – -46,046 Closed
XT
42
XTX Topco
Cayman Islands
– – -30,138 Closed
Susquehanna International Group
43
Susquehanna International Group
Pennsylvania
– – -29,755 Closed
PI
44
PFG Investments
New York
– – -24,534 Closed
HF
45
HRT Financial
New York
– – -14,692 Closed
Dimensional Fund Advisors
46
Dimensional Fund Advisors
Texas
– – -10,003 Closed
National Bank of Canada
47
National Bank of Canada
Quebec, Canada
– – -10,000 Closed
TRCT
48
Tower Research Capital (TRC)
New York
– – -929 Closed
Osaic Holdings
49
Osaic Holdings
Arizona
– – -295 Closed
RMP
50
Richards, Merrill & Peterson
Washington
– – -150 Closed
1
2
3