Simplex Trading
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Simplex Trading’s Spero Therapeutics SPRO Stock Holding History

Simplex Trading’s Portfolio SPRO Stock Details SPRO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$70.9K Sell
30,304
-5,382
-15% -$12.8K ﹤0.01% 5479
2025
Q4 		$83.1K Buy
35,686
+28,068
+368% +$65.2K ﹤0.01% 5181
2025
Q3 		$14K Sell
7,618
-22,704
-75% -$49.9K ﹤0.01% 7663
2025
Q2 		$87K Buy
30,322
+25,224
+495% +$36.3K ﹤0.01% 5383
2025
Q1 		$3K Sell
5,098
-12
-0.2% -$10 ﹤0.01% 7883
2024
Q4 		$5K Buy
5,110
+4,189
+455% +$4.98K ﹤0.01% 7657
2024
Q3 		$1K Buy
+921
New +$1.24K ﹤0.01% 8277
2023
Q3 		– Sell
-2,281
Closed -$3.16K – 9755
2023
Q2 		$3K Buy
+2,281
New +$3.9K ﹤0.01% 8286
2023
Q1 		– Sell
-9,206
Closed -$15.4K – 10063
2022
Q4 		$15K Buy
9,206
+8,206
+821% +$15.3K ﹤0.01% 7169
2022
Q3 		$2K Sell
1,000
-8,300
-89% -$8.25K ﹤0.01% 9360
2022
Q2 		$6K Buy
9,300
+2,954
+47% +$8.59K ﹤0.01% 8752
2022
Q1 		$55K Buy
+6,346
New +$65K ﹤0.01% 7007
2021
Q3 		– Sell
-507
Closed -$8.14K – 9879
2021
Q2 		$7K Buy
+507
New +$7.08K ﹤0.01% 9303
2021
Q1 		– Sell
-606
Closed -$10.7K – 9950
2020
Q4 		$11K Buy
+606
New +$9.45K ﹤0.01% 7366
2020
Q3 		– Sell
-200
Closed -$2.37K – 8465
2020
Q2 		$2K Buy
+200
New +$2.25K ﹤0.01% 7278

Other funds holding SPRO

GP
GSK plc London $599M AUM
P
Pfizer New York $239M AUM 232.47% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
AI
Alphabet Inc Mountain View, California $4.02B AUM 215.74% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $124B AUM 33.93% 1-Year Est. Return
AFM
Anson Funds Management Dallas, Texas $2.29B AUM 370.24% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return

Simplex Trading's SPRO Position: Q1 2026 in Review

Simplex Trading reduced its Spero Therapeutics (SPRO) stake by 15% in Q1 2026, selling an estimated $12.8K and leaving 30,304 shares worth $70.9K. The position accounts for ﹤0.01% of the portfolio, ranked #5479.

Simplex Trading first reported a position in SPRO in Q2 2020 and has held it in 15 quarters since. The position peaked at $87K in Q2 2025. 50 funds tracked by Wall St. Rank hold SPRO as of Q1 2026.

  • Simplex Trading held 30,304 shares of Spero Therapeutics worth $70.9K as of Q1 2026.
  • Simplex Trading sold 5,382 Spero Therapeutics shares in Q1 2026, an estimated $12.8K.
  • Spero Therapeutics made up ﹤0.01% of Simplex Trading's portfolio in Q1 2026, its #5479 holding.
  • Simplex Trading first reported a position in Spero Therapeutics in Q2 2020 and has held it in 15 quarters since.
  • Simplex Trading's Spero Therapeutics position peaked at $87K in Q2 2025.
  • 50 funds tracked by Wall St. Rank held Spero Therapeutics as of Q1 2026.

Based on Simplex Trading's 13F filing for Q1 2026, filed 14 May 2026.