Simplex Trading
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Simplex Trading’s Spero Therapeutics SPRO Stock Holding History

Simplex Trading’s Portfolio SPRO Stock Details SPRO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$123K Buy
55,800
+22,600
+68% +$59.1K ﹤0.01% 5296
2026
Q1 		$77.7K Buy
33,200
+14,800
+80% +$35.1K ﹤0.01% 5370
2025
Q4 		$42.9K Sell
18,400
-9,700
-35% -$22.5K ﹤0.01% 5802
2025
Q3 		$52K Sell
28,100
-140,700
-83% -$309K ﹤0.01% 6432
2025
Q2 		$489K Buy
168,800
+165,700
+5,345% +$238K ﹤0.01% 3530
2025
Q1 		$2K Buy
+3,100
New +$2.62K ﹤0.01% 8073
2023
Q3 		– Sell
-3,800
Closed -$5K – 9756
2023
Q2 		$5K Buy
+3,800
New +$6.5K ﹤0.01% 7959
2023
Q1 		– Sell
-26,900
Closed -$46K – 10064
2022
Q4 		$46K Buy
26,900
+24,000
+828% +$44.8K ﹤0.01% 5996
2022
Q3 		$5K Sell
2,900
-7,000
-71% -$6.96K ﹤0.01% 8819
2022
Q2 		$7K Buy
+9,900
New +$28.8K ﹤0.01% 8628
2021
Q4 		– Sell
-1,600
Closed -$26K – 11369
2021
Q3 		$26K Buy
1,600
+1,000
+167% +$16K ﹤0.01% 8207
2021
Q2 		$8K Buy
600
+564
+1,567% +$7.88K ﹤0.01% 9244
2021
Q1 		$52K Buy
36
+27
+300% +$475 ﹤0.01% 6572
2020
Q4 		$17K Buy
+9
New +$140 ﹤0.01% 7089

Other funds holding SPRO

GP
GSK plc London $602M AUM
P
Pfizer New York $170M AUM 191.09% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Renaissance Technologies
Renaissance Technologies New York $72.6B AUM 54.88% 1-Year Est. Return
AI
Alphabet Inc Mountain View, California $99.1B AUM 124.46% 1-Year Est. Return
Susquehanna International Group
Susquehanna International Group Bala Cynwyd, Pennsylvania $1.28T AUM 58.89% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return
Raymond James Financial
Raymond James Financial St Petersburg, Florida $369B AUM 28.27% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return

Simplex Trading's SPRO Position: Q2 2026 in Review

Simplex Trading increased its Spero Therapeutics (SPRO) stake by 102% in Q2 2026, buying an estimated $81.1K and bringing the position to 61,312 shares worth $135K. The position accounts for ﹤0.01% of the portfolio, ranked #5191.

Simplex Trading first reported a position in SPRO in Q2 2020 and has held it in 16 quarters since. 60 funds tracked by Wall St. Rank hold SPRO as of Q2 2026.

  • Simplex Trading held 61,312 shares of Spero Therapeutics worth $135K as of Q2 2026.
  • Simplex Trading bought 31,008 Spero Therapeutics shares in Q2 2026, an estimated $81.1K.
  • Spero Therapeutics made up ﹤0.01% of Simplex Trading's portfolio in Q2 2026, its #5191 holding.
  • Simplex Trading first reported a position in Spero Therapeutics in Q2 2020 and has held it in 16 quarters since.
  • 60 funds tracked by Wall St. Rank held Spero Therapeutics as of Q2 2026.

Based on Simplex Trading's 13F filing for Q2 2026, filed 12 Aug 2026.