Simplex Trading
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Simplex Trading’s Spero Therapeutics SPRO Stock Holding History

Simplex Trading’s Portfolio SPRO Stock Details SPRO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$234 Sell
100
-1,100
-92% -$2.61K ﹤0.01% 8822
2025
Q4 		$2.8K Sell
1,200
-14,700
-92% -$34.1K ﹤0.01% 7715
2025
Q3 		$29K Sell
15,900
-26,900
-63% -$59.1K ﹤0.01% 7016
2025
Q2 		$124K Buy
+42,800
New +$61.6K ﹤0.01% 5022
2024
Q3 		– Sell
-4,600
Closed -$5K – 9519
2024
Q2 		$5K Sell
4,600
-4,200
-48% -$6.33K ﹤0.01% 7907
2024
Q1 		$15K Buy
+8,800
New +$13.8K ﹤0.01% 7339
2023
Q3 		– Sell
-700
Closed -$1K – 9754
2023
Q2 		$1K Sell
700
-13,700
-95% -$23.5K ﹤0.01% 8721
2023
Q1 		$20K Sell
14,400
-51,600
-78% -$86.4K ﹤0.01% 6924
2022
Q4 		$114K Buy
66,000
+14,800
+29% +$27.6K ﹤0.01% 4923
2022
Q3 		$102K Buy
51,200
+49,000
+2,227% +$48.7K ﹤0.01% 5502
2022
Q2 		$1K Sell
2,200
-1,200
-35% -$3.49K ﹤0.01% 9674
2022
Q1 		$29K Sell
3,400
-25,800
-88% -$264K ﹤0.01% 7821
2021
Q4 		$467K Buy
29,200
+23,700
+431% +$376K ﹤0.01% 3906
2021
Q3 		$90K Buy
5,500
+1,000
+22% +$16K ﹤0.01% 6769
2021
Q2 		$62K Buy
4,500
+4,445
+8,082% +$62.1K ﹤0.01% 7389
2021
Q1 		$80K Buy
55
+1
+2% +$18 ﹤0.01% 6051
2020
Q4 		$104K Buy
54
+47
+671% +$733 ﹤0.01% 5408
2020
Q3 		$7K Buy
+7
New +$83 ﹤0.01% 6974
2019
Q2 		– Sell
-1
Closed -$1K – 7748
2019
Q1 		$1K Buy
+1
New +$11 ﹤0.01% 6935

Other funds holding SPRO

GP
GSK plc London $599M AUM
P
Pfizer New York $239M AUM 232.47% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
AI
Alphabet Inc Mountain View, California $4.02B AUM 215.74% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $124B AUM 33.93% 1-Year Est. Return
AFM
Anson Funds Management Dallas, Texas $2.29B AUM 370.24% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return

Simplex Trading's SPRO Position: Q1 2026 in Review

Simplex Trading reduced its Spero Therapeutics (SPRO) stake by 15% in Q1 2026, selling an estimated $12.8K and leaving 30,304 shares worth $70.9K. The position accounts for ﹤0.01% of the portfolio, ranked #5479.

Simplex Trading first reported a position in SPRO in Q2 2020 and has held it in 15 quarters since. The position peaked at $87K in Q2 2025. 50 funds tracked by Wall St. Rank hold SPRO as of Q1 2026.

  • Simplex Trading held 30,304 shares of Spero Therapeutics worth $70.9K as of Q1 2026.
  • Simplex Trading sold 5,382 Spero Therapeutics shares in Q1 2026, an estimated $12.8K.
  • Spero Therapeutics made up ﹤0.01% of Simplex Trading's portfolio in Q1 2026, its #5479 holding.
  • Simplex Trading first reported a position in Spero Therapeutics in Q2 2020 and has held it in 15 quarters since.
  • Simplex Trading's Spero Therapeutics position peaked at $87K in Q2 2025.
  • 50 funds tracked by Wall St. Rank held Spero Therapeutics as of Q1 2026.

Based on Simplex Trading's 13F filing for Q1 2026, filed 14 May 2026.