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Spero Therapeutics
SPRO

Overview Fund Activity

42 hedge funds and large institutions have $31.9M invested in Spero Therapeutics in 2025 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 9 increasing their positions, 9 reducing their positions, and 11 closing their positions.

Holders
42
Holders Change
+3
Holders Change %
+7.69%
% of All Funds
0.56%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
14
Increased
9
Reduced
9
Closed
11
Calls
$447K
Puts
$1.24M
Net Calls
-$794K
Net Calls Change
-$799K

Top Buyers

1
SSA
1
Schonfeld Strategic Advisors
New York
$1.48M
2
EI
2
EAM Investors
California
$694K
3
Vanguard Group
3
Vanguard Group
Pennsylvania
$5.66M
4
SCM
4
Stonepine Capital Management
Oregon
$455K
5
ICM
5
Ionic Capital Management
New York
$435K

Top Sellers

1
AFM
1
Anson Funds Management
Texas
$4.68M
2
Acadian Asset Management
2
Acadian Asset Management
Massachusetts
$327K
3
ACM
3
ADAR1 Capital Management
Texas
$417K
4
M
4
Murchinson
Ontario, Canada
$0
5
Renaissance Technologies
5
Renaissance Technologies
New York
$2.41M
Name Market Value Shares Shares
Change 		Shares
Change %
CSS
26
Cubist Systematic Strategies
Connecticut
$78.7K 27,140 +27,140 New
Invesco
27
Invesco
Georgia
$43.4K 14,968 +14,968 New
TYCC
28
Texas Yale Capital Corp
Florida
$29K 10,000 – –
Morgan Stanley
29
Morgan Stanley
New York
$26.7K 9,221 +2,250 +32%
Group One Trading
30
Group One Trading
Illinois
$23.9K 8,239 +8,239 New
UBS Group
31
UBS Group
Switzerland
$23.8K 8,194 +5,368 +190%
Royal Bank of Canada
32
Royal Bank of Canada
Ontario, Canada
$17K 5,739 +5,739 New
Bank of America
33
Bank of America
North Carolina
$16.3K 5,633 +68 +1%
Raymond James Financial
34
Raymond James Financial
Florida
$8.94K 3,082 +3,082 New
CFB
35
Cullen/Frost Bankers
Texas
$5.8K 2,000 – –
TRCT
36
Tower Research Capital (TRC)
New York
$1.75K 603 +603 New
JPMorgan Chase & Co
37
JPMorgan Chase & Co
New York
$684 236 -60,581 -100%
Wells Fargo
38
Wells Fargo
California
$580 200 – –
US Bancorp
39
US Bancorp
Minnesota
$438 151 – –
NA
40
NewEdge Advisors
Louisiana
$290 100 – –
SS
41
SBI Securities
Japan
$180 62 +2 +3%
BNP Paribas Financial Markets
42
BNP Paribas Financial Markets
France
$116 40 +28 +233%
M
43
Murchinson
Ontario, Canada
– – -873,910 Closed
AVLSA
44
Atlas Venture Life Science Advisors
Massachusetts
– – -305,255 Closed
Mackenzie Financial
45
Mackenzie Financial
Ontario, Canada
– – -209,031 Closed
DCM
46
DAFNA Capital Management
California
– – -125,000 Closed
Squarepoint
47
Squarepoint
New York
– – -92,939 Closed
Prudential Financial
48
Prudential Financial
New Jersey
– – -56,000 Closed
DIM
49
DLK Investment Management
California
– – -29,825 Closed
EWA
50
EP Wealth Advisors
California
– – -16,500 Closed
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