SEPN

Septerna, Inc. Common Stock
SEPN

Overview Fund Activity

88 hedge funds and large institutions have $468M invested in Septerna, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 30 increasing their positions, 19 reducing their positions, and 6 closing their positions.

Holders
88
Holders Change
+17
Holders Change %
+23.94%
% of All Funds
1.18%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
25
Increased
30
Reduced
19
Closed
6
Calls
$148K
Puts
$7M
Net Calls
-$6.85M
Net Calls Change
-$6.56M

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$49.5M
2
PA
2
Perceptive Advisors
New York
$5.72M
3
VA
3
VR Adviser
New York
$5.71M
4
Vanguard Group
4
Vanguard Group
Pennsylvania
$14.9M
5
BlackRock
5
BlackRock
New York
$14.7M

Top Sellers

1
DTC
1
Deep Track Capital
Connecticut
$1.29M
2
CCM
2
Catalio Capital Management
New York
$3.11M
3
SCM
3
Soleus Capital Management
Connecticut
$798K
4
Millennium Management
4
Millennium Management
New York
$549K
5
WP
5
Woodline Partners
California
$2.99M
Name Market Value Shares Shares
Change 		Shares
Change %
LGM
26
Logos Global Management
California
$1.15M 109,202 -25,000 -19%
Bank of America
27
Bank of America
North Carolina
$1.05M 99,213 +87,654 +758%
Morgan Stanley
28
Morgan Stanley
New York
$897K 84,860 -6,184 -7%
Two Sigma Investments
29
Two Sigma Investments
New York
$821K 77,642 +2,801 +4%
SCM
30
Soleus Capital Management
Connecticut
$798K 75,456 -675,897 -90%
UBS Group
31
UBS Group
Switzerland
$765K 72,335 -167,595 -70%
RC
32
Rangeley Capital
Connecticut
$619K 58,605 +5,655 +11%
NL
33
Nuveen LLC
North Carolina
$613K 57,971 +34,010 +142%
Millennium Management
34
Millennium Management
New York
$549K 51,944 -384,620 -88%
Bank of New York Mellon
35
Bank of New York Mellon
New York
$513K 48,489 +10,113 +26%
Barclays
36
Barclays
United Kingdom
$377K 35,706 +12,973 +57%
Alyeska Investment Group
37
Alyeska Investment Group
Illinois
$370K 35,000 – –
UBS AM
38
UBS AM
Illinois
$303K 28,700 +28,700 New
RhumbLine Advisers
39
RhumbLine Advisers
Massachusetts
$302K 28,572 +5,254 +23%
T. Rowe Price Associates
40
T. Rowe Price Associates
Maryland
$264K 24,902 +1,945 +8%
BFM
41
Boothbay Fund Management
New York
$255K 24,142 +24,142 New
GCP
42
GSA Capital Partners
United Kingdom
$249K 23,527 +5,228 +29%
Simplex Trading
43
Simplex Trading
Illinois
$248K 23,525 +23,495 +78,317%
XT
44
XTX Topco
Cayman Islands
$236K 22,330 -15,020 -40%
AllianceBernstein
45
AllianceBernstein
Tennessee
$234K 22,100 +22,100 New
Citadel Advisors
46
Citadel Advisors
Florida
$188K 17,774 +17,774 New
Tudor Investment Corp
47
Tudor Investment Corp
Connecticut
$177K 16,761 +16,761 New
Wells Fargo
48
Wells Fargo
California
$156K 14,717 +3,848 +35%
MIM
49
MetLife Investment Management
New Jersey
$145K 13,685 +13,685 New
CWM
50
Congress Wealth Management
Massachusetts
$133K 12,589 +12,589 New
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