SEPN

Septerna Inc

122 hedge funds and large institutions have $1.27B invested in Septerna Inc in 2025 Q4 according to their latest regulatory filings, with 45 funds opening new positions, 31 increasing their positions, 27 reducing their positions, and 5 closing their positions.

New
Increased
Maintained
Reduced
Closed

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding

Funds holding:

more funds holding in top 10

Funds holding in top 10:

15% more repeat investments, than reductions

Existing positions increased: 31 | Existing positions reduced: 27

1.9% more ownership

Funds ownership: 99.92%101.81% (+1.9%)

54% less call options, than puts

Call options by funds: $2.3M | Put options by funds: $5.01M

Holders
122
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
5
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$2.3M
Puts
$5.01M
Net Calls
Net Calls Change

Top Buyers

1 +$30.1M
2 +$14.8M
3 +$13M
4
SCM
Soleus Capital Management
Connecticut
+$8.72M
5
BlackRock
BlackRock
New York
+$8.16M

Top Sellers

1 -$54.8M
2 -$6.61M
3 -$5.33M
4
SL
Siren LLC
Connecticut
-$4.84M
5
SCM
Sio Capital Management
New York
-$3.56M
Name Holding Trade Value Shares
Change
Change in
Stake
CUAMC
76
China Universal Asset Management Company
China
$287K
BBA
77
Baader Bank Aktiengesellschaft
Germany
$279K
Mirae Asset Global ETFs Holdings
78
Mirae Asset Global ETFs Holdings
Hong Kong
$277K
AI
79
Atom Investors
Texas
$273K
Citigroup
80
Citigroup
New York
$267K
GCM
81
Graham Capital Management
Connecticut
$250K
JF
82
Jump Financial
Illinois
$234K
Bank of Nova Scotia
83
Bank of Nova Scotia
Ontario, Canada
$231K
AQR Capital Management
84
AQR Capital Management
Connecticut
$218K
New York State Common Retirement Fund
85
New York State Common Retirement Fund
New York
$156K
BNP Paribas Financial Markets
86
BNP Paribas Financial Markets
France
$152K
PFSRSONJ
87
Police & Firemen's Retirement System of New Jersey
New Jersey
$144K
Balyasny Asset Management
88
Balyasny Asset Management
Illinois
$99.6K
Fidelity Investments
89
Fidelity Investments
Massachusetts
$92.2K
Mirae Asset Global Investments
90
Mirae Asset Global Investments
South Korea
$60.7K
TRCT
91
Tower Research Capital (TRC)
New York
$60.1K
AIP
92
Ameritas Investment Partners
Nebraska
$54.2K
Legal & General Group
93
Legal & General Group
United Kingdom
$54.2K
C
94
Covestor
United Kingdom
$54K
CIAM
95
Caitong International Asset Management
Hong Kong
$53K
California State Teachers Retirement System (CalSTRS)
96
California State Teachers Retirement System (CalSTRS)
California
$36.7K
GRP
97
Global Retirement Partners
California
$35K
SCM
98
Sterling Capital Management
North Carolina
$34.3K
S
99
SignatureFD
Georgia
$27.6K
Group One Trading
100
Group One Trading
Illinois
$26.3K