SEPN

Septerna, Inc. Common Stock
SEPN

Overview Fund Activity

88 hedge funds and large institutions have $468M invested in Septerna, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 30 increasing their positions, 19 reducing their positions, and 6 closing their positions.

Holders
88
Holders Change
+17
Holders Change %
+23.94%
% of All Funds
1.18%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
25
Increased
30
Reduced
19
Closed
6
Calls
$148K
Puts
$7M
Net Calls
-$6.85M
Net Calls Change
-$6.56M

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$49.5M
2
PA
2
Perceptive Advisors
New York
$5.72M
3
VA
3
VR Adviser
New York
$5.71M
4
Vanguard Group
4
Vanguard Group
Pennsylvania
$14.9M
5
BlackRock
5
BlackRock
New York
$14.7M

Top Sellers

1
DTC
1
Deep Track Capital
Connecticut
$1.29M
2
CCM
2
Catalio Capital Management
New York
$3.11M
3
SCM
3
Soleus Capital Management
Connecticut
$798K
4
Millennium Management
4
Millennium Management
New York
$549K
5
WP
5
Woodline Partners
California
$2.99M
Name Market Value Shares Shares
Change 		Shares
Change %
CIAM
76
Caitong International Asset Management
Hong Kong
$6.4K 605 +605 New
GI
77
GAMMA Investing
California
$6.1K 577 +143 +33%
SCM
78
Sterling Capital Management
North Carolina
$6.1K 577 +420 +268%
US Bancorp
79
US Bancorp
Minnesota
$2.8K 265 +265 New
Raymond James Financial
80
Raymond James Financial
Florida
$2.35K 222 +222 New
Comerica Bank
81
Comerica Bank
Texas
$2.24K 212 +212 New
Nisa Investment Advisors
82
Nisa Investment Advisors
Missouri
$1.51K 143 +9 +7%
Osaic Holdings
83
Osaic Holdings
Arizona
$1.21K 114 +114 New
FFO
84
Fortitude Family Office
Arizona
$750 71 +71 New
SS
85
SBI Securities
Japan
$529 50 +50 New
RIL
86
Rothschild Investment LLC
Illinois
$317 30 +30 New
EWA
87
EverSource Wealth Advisors
Alabama
$233 22 +22 New
National Bank of Canada
88
National Bank of Canada
Quebec, Canada
$85 8 – –
SCM
89
Stonepine Capital Management
Oregon
– – -68,084 Closed
Swiss National Bank
90
Swiss National Bank
Switzerland
– – -30,100 Closed
SIP
91
Stoneridge Investment Partners
Pennsylvania
– – -18,477 Closed
CPIG
92
Chicago Partners Investment Group
Illinois
– – -10,954 Closed
CF
93
Corebridge Financial
Texas
– – -9,102 Closed
KK
94
KLP Kapitalforvaltning
Norway
– – -8,400 Closed
Jane Street
95
Jane Street
New York
– – – –
1 2 3
4