SEPN

Septerna Inc

122 hedge funds and large institutions have $1.27B invested in Septerna Inc in 2025 Q4 according to their latest regulatory filings, with 45 funds opening new positions, 31 increasing their positions, 27 reducing their positions, and 5 closing their positions.

New
Increased
Maintained
Reduced
Closed

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding

Funds holding:

more funds holding in top 10

Funds holding in top 10:

15% more repeat investments, than reductions

Existing positions increased: 31 | Existing positions reduced: 27

1.9% more ownership

Funds ownership: 99.92%101.81% (+1.9%)

54% less call options, than puts

Call options by funds: $2.3M | Put options by funds: $5.01M

Holders
122
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
5
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$2.3M
Puts
$5.01M
Net Calls
Net Calls Change

Top Buyers

1 +$30.1M
2 +$14.8M
3 +$13M
4
SCM
Soleus Capital Management
Connecticut
+$8.72M
5
BlackRock
BlackRock
New York
+$8.16M

Top Sellers

1 -$54.8M
2 -$6.61M
3 -$5.33M
4
SL
Siren LLC
Connecticut
-$4.84M
5
SCM
Sio Capital Management
New York
-$3.56M
Name Holding Trade Value Shares
Change
Change in
Stake
GI
101
GAMMA Investing
California
$25.5K
Carson Wealth (CWM LLC)
102
Carson Wealth (CWM LLC)
Nebraska
$25K
GFM
103
GF Fund Management
China
$24.5K
QL
104
Quarry LP
New York
$20.2K
AB
105
Amalgamated Bank
New York
$19K
Royal Bank of Canada
106
Royal Bank of Canada
Ontario, Canada
$18K
Nisa Investment Advisors
107
Nisa Investment Advisors
Missouri
$9.51K
PWPS
108
Pinnacle Wealth Planning Services
Ohio
$8.98K
VCM
109
Versant Capital Management
Arizona
$7.28K
PNC Financial Services Group
110
PNC Financial Services Group
Pennsylvania
$5.52K
US Bancorp
111
US Bancorp
Minnesota
$5.3K
NEWAS
112
N.E.W. Advisory Services
Wisconsin
$5.02K
Daiwa Securities Group
113
Daiwa Securities Group
Japan
$4K
FFO
114
Fortitude Family Office
Arizona
$1.98K
EWA
115
EverSource Wealth Advisors
Alabama
$1.76K
MPWT
116
MassMutual Private Wealth & Trust
Connecticut
$1.76K
SS
117
SBI Securities
Japan
$1.53K
CFM
118
Cornerstone Financial Management
Massachusetts
$1.45K
RIL
119
Rothschild Investment LLC
Illinois
$836
ACM
120
Aster Capital Management
United Arab Emirates
$558
AAP
121
Arax Advisory Partners
Colorado
$84
FFA
122
Farther Finance Advisors
California
$28
CC
123
Checkpoint Capital
California
SCM
124
Sio Capital Management
New York
Walleye Capital
125
Walleye Capital
New York