Two Sigma Investments
SEPN

Two Sigma Investments’s Septerna Inc SEPN Stock Holding History

Two Sigma Investments’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$1.81M Sell
75,367
-17,442
-19% -$459K ﹤0.01% 2829
2025
Q4 		$2.59M Buy
92,809
+475
+0.5% +$11.3K ﹤0.01% 2255
2025
Q3 		$1.74M Buy
92,334
+14,692
+19% +$193K ﹤0.01% 2221
2025
Q2 		$821K Buy
77,642
+2,801
+4% +$23.1K ﹤0.01% 2355
2025
Q1 		$433K Buy
+74,841
New +$854K ﹤0.01% 2579

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Two Sigma Investments's SEPN Position: Q1 2026 in Review

Two Sigma Investments reduced its Septerna Inc (SEPN) stake by 19% in Q1 2026, selling an estimated $459K and leaving 75,367 shares worth $1.81M. The position accounts for ﹤0.01% of the portfolio, ranked #2829.

Two Sigma Investments first reported a position in SEPN in Q1 2025 and has held it in 5 quarters since. The position peaked at $2.59M in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • Two Sigma Investments held 75,367 shares of Septerna Inc worth $1.81M as of Q1 2026.
  • Two Sigma Investments sold 17,442 Septerna Inc shares in Q1 2026, an estimated $459K.
  • Septerna Inc made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2829 holding.
  • Two Sigma Investments first reported a position in Septerna Inc in Q1 2025 and has held it in 5 quarters since.
  • Two Sigma Investments's Septerna Inc position peaked at $2.59M in Q4 2025.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.