Renaissance Technologies
SEPN

Renaissance Technologies’s Septerna Inc SEPN Stock Holding History

Renaissance Technologies’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$1.39M Buy
41,419
+3,719
+10% +$106K ﹤0.01% 2164
2026
Q1 		$906K Buy
+37,700
New +$991K ﹤0.01% 2323

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM

Renaissance Technologies's SEPN Position: Q2 2026 in Review

Renaissance Technologies increased its Septerna Inc (SEPN) stake by 9.9% in Q2 2026, buying an estimated $106K and bringing the position to 41,419 shares worth $1.39M. The position accounts for ﹤0.01% of the portfolio, ranked #2164.

Renaissance Technologies first reported a position in SEPN in Q1 2026 and has held it in 2 quarters since. 154 funds tracked by Wall St. Rank hold SEPN as of Q2 2026.

  • Renaissance Technologies held 41,419 shares of Septerna Inc worth $1.39M as of Q2 2026.
  • Renaissance Technologies bought 3,719 Septerna Inc shares in Q2 2026, an estimated $106K.
  • Septerna Inc made up ﹤0.01% of Renaissance Technologies's portfolio in Q2 2026, its #2164 holding.
  • Renaissance Technologies first reported a position in Septerna Inc in Q1 2026 and has held it in 2 quarters since.
  • 154 funds tracked by Wall St. Rank held Septerna Inc as of Q2 2026.

Based on Renaissance Technologies's 13F filing for Q2 2026, filed 13 Aug 2026.