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SEPN

Septerna Inc
SEPN

124 hedge funds and large institutions have $1.1B invested in Septerna Inc in 2026 Q1 according to their latest regulatory filings, with 28 funds opening new positions, 43 increasing their positions, 30 reducing their positions, and 24 closing their positions.

New
Increased
Maintained
Reduced
Closed

43% more repeat investments, than reductions

Existing positions increased: 43 | Existing positions reduced: 30

17% more first-time investments, than exits

New positions opened: 28 | Existing positions closed: 24

2% more funds holding

Funds holding: 122 → 124 (+2)

0% less ownership

Funds ownership: 101.82% → 101.82% (-0%)

14% less capital invested

Capital invested by funds: $1.27B → $1.1B (-$172M)

20% less funds holding in top 10

Funds holding in top 10: 5 → 4 (-1)

Holders
124
Holders Change
+2
Holders Change %
+1.64%
% of All Funds
1.53%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
28
Increased
43
Reduced
30
Closed
24
Calls
$1.81M
Puts
–
Net Calls
+$1.81M
Net Calls Change
+$4.52M

Top Buyers

1
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$23.4M
2
Primecap Management
Primecap Management
California
+$13.2M
3
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$6.13M
4
Goldman Sachs
Goldman Sachs
New York
+$5.03M
5
FLAM
First Light Asset Management
Minnesota
+$2.95M

Top Sellers

1
PA
Perceptive Advisors
New York
-$12.1M
2
DCM
Driehaus Capital Management
Illinois
-$10.9M
3
WP
Woodline Partners
California
-$10.7M
4
BI
BVF Inc
California
-$9.66M
5
Marshall Wace
Marshall Wace
United Kingdom
-$4.92M
Name Holding Trade Value Shares
Change 		Change in
Stake
Charles Schwab
26
Charles Schwab
California
$4.36M -$149K -5,661 -3%
Northern Trust
27
Northern Trust
Illinois
$3.95M +$272K +10,334 +7%
VFT
28
Vanguard Fiduciary Trust
Pennsylvania
$3.71M +$4.06M +154,484 New
Millennium Management
29
Millennium Management
New York
$2.98M +$437K +16,638 +15%
UBS Group
30
UBS Group
Switzerland
$2.81M +$1.27M +48,162 +70%
Morgan Stanley
31
Morgan Stanley
New York
$2.66M +$172K +6,545 +6%
HSA
32
Hussman Strategic Advisors
Maryland
$2.52M +$2.76M +105,000 New
CC
33
Checkpoint Capital
California
$2.41M +$2.64M +100,300 New
Federated Hermes
34
Federated Hermes
Pennsylvania
$2.15M +$273K +10,396 +13%
Invesco
35
Invesco
Georgia
$1.99M -$2.08M -79,146 -49%
JP Morgan Chase
36
JP Morgan Chase
New York
$1.97M +$429K +16,336 +24%
Two Sigma Investments
37
Two Sigma Investments
New York
$1.81M -$459K -17,442 -19%
LP
38
Longaeva Partners
Illinois
$1.79M +$648K +24,665 +49%
American Century Companies
39
American Century Companies
Missouri
$1.47M +$279K +10,601 +21%
Bank of New York Mellon
40
Bank of New York Mellon
New York
$1.41M +$88.8K +3,377 +6%
JF
41
Jump Financial
Illinois
$1.27M +$1.17M +44,612 +531%
SI
42
Sofinnova Investments
California
$1.14M +$1.25M +47,506 New
Marshall Wace
43
Marshall Wace
United Kingdom
$957K -$4.92M -187,061 -82%
RC
44
Rangeley Capital
Connecticut
$956K -$683K -26,000 -40%
Renaissance Technologies
45
Renaissance Technologies
New York
$906K +$991K +37,700 New
XT
46
XTX Topco
Cayman Islands
$882K +$352K +13,408 +58%
TI
47
Trexquant Investment
Connecticut
$848K -$229K -8,704 -20%
Alyeska Investment Group
48
Alyeska Investment Group
Illinois
$841K – – –
Acadian Asset Management
49
Acadian Asset Management
Massachusetts
$741K +$2.65K +101 +0.3%
N
50
Nuveen
North Carolina
$701K +$88.8K +3,378 +13%
1
2
3 4 5

SEPN Hedge Fund Activity: Q1 2026 in Review

124 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q1 2026, worth a combined $1.1B — down 14% from $1.27B a quarter earlier.

Buyers outnumbered sellers: 28 funds opened new SEPN positions and 24 closed out — a net gain of 4 holders — while 43 added to existing stakes and 30 trimmed.

The largest buyer was Janus Henderson Group, opening a new position worth an estimated $23.4M. The largest seller was Perceptive Advisors, exiting entirely with an estimated $12.1M sold.

  • 124 institutional investors held Septerna Inc (SEPN) as of Q1 2026, up from 122 in Q4 2025.
  • Funds reported $1.1B of Septerna Inc stock for Q1 2026, down 14% quarter-over-quarter.
  • 28 funds opened new Septerna Inc positions in Q1 2026 and 24 closed out, a net change of +4 holders.
  • The largest Septerna Inc buyer in Q1 2026 was Janus Henderson Group, an estimated $23.4M added.
  • The largest Septerna Inc seller in Q1 2026 was Perceptive Advisors, an estimated $12.1M sold.

Based on aggregated 13F filings for Q1 2026.