BBA

Baker Bros. Advisors Portfolio holdings

AUM $10.3B
This Quarter Return
+3.62%
1 Year Return
+63.34%
3 Year Return
+231.6%
5 Year Return
+293.68%
10 Year Return
+1,612.7%
AUM
$22.8B
AUM Growth
+$22.8B
Cap. Flow
-$610M
Cap. Flow %
-2.68%
Top 10 Hldgs %
81.57%
Holding
135
New
6
Increased
16
Reduced
10
Closed
15

Top Buys

1
VERV
Verve Therapeutics
VERV
$85.3M
2
LEGN icon
Legend Biotech
LEGN
$63.6M
3
APLS icon
Apellis Pharmaceuticals
APLS
$37.8M
4
HRTX icon
Heron Therapeutics
HRTX
$33.2M
5
JBIO
Jade Biosciences, Inc. Common Stock
JBIO
$32.6M

Top Sells

1
ALXN
Alexion Pharmaceuticals Inc
ALXN
$611M
2
NVTA
Invitae Corporation
NVTA
$186M
3
PTGX icon
Protagonist Therapeutics
PTGX
$44M
4
CCXI
ChemoCentryx, Inc.
CCXI
$33.7M
5
ALT icon
Altimmune
ALT
$16.6M

Sector Composition

1 Healthcare 97.75%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
RETA
51
DELISTED
Reata Pharmaceuticals, Inc. Class A Common Stock
RETA
$31.7M 0.14%
223,976
– –
NVAX icon
52
Novavax
NVAX
$1.2B
$30.5M 0.13%
143,756
– –
ALKS icon
53
Alkermes
ALKS
$4.95B
$30.1M 0.13%
1,228,170
– –
BCEL
54
DELISTED
Atreca, Inc. Class A Common Stock
BCEL
$30.1M 0.13%
3,532,760
– –
DSGN icon
55
Design Therapeutics
DSGN
$339M
$28.6M 0.13%
1,436,636
– –
OPT
56
DELISTED
Opthea Limited American Depositary Shares
OPT
$27.1M 0.12%
3,412,062
+103,357
+3% +$821K
ACHL
57
DELISTED
Achilles Therapeutics plc American Depositary Shares
ACHL
$25.4M 0.11%
2,591,366
– –
SYRE icon
58
Spyre Therapeutics
SYRE
$1.02B
$23.7M 0.1%
3,410,106
– –
PTGX icon
59
Protagonist Therapeutics
PTGX
$3.62B
$20.4M 0.09%
455,276
-980,916
-68% -$44M
CYT
60
DELISTED
Cyteir Therapeutics, Inc. Common Stock
CYT
$17.4M 0.08%
+812,640
New +$17.4M
CRNX icon
61
Crinetics Pharmaceuticals
CRNX
$3.26B
$17.4M 0.08%
920,656
+304,136
+49% +$5.73M
OTIC
62
DELISTED
Otonomy, Inc.
OTIC
$16.1M 0.07%
7,222,474
+2,400
+0% +$5.35K
KDNY
63
DELISTED
Chinook Therapeutics, Inc. Common Stock
KDNY
$15.3M 0.07%
1,080,393
+331,700
+44% +$4.68M
AUPH icon
64
Aurinia Pharmaceuticals
AUPH
$1.58B
$14.5M 0.06%
1,119,962
-290,102
-21% -$3.76M
ALBO
65
DELISTED
Albireo Pharma, Inc. Common Stock
ALBO
$14.5M 0.06%
412,466
– –
XENE icon
66
Xenon Pharmaceuticals
XENE
$2.99B
$14M 0.06%
751,639
– –
MIRM icon
67
Mirum Pharmaceuticals
MIRM
$3.75B
$11.2M 0.05%
647,313
– –
ANAB icon
68
AnaptysBio
ANAB
$630M
$11.1M 0.05%
427,179
– –
EWTX icon
69
Edgewise Therapeutics
EWTX
$1.54B
$10.7M 0.05%
500,000
– –
ALT icon
70
Altimmune
ALT
$325M
$10.6M 0.05%
1,072,038
-1,686,480
-61% -$16.6M
CBAY
71
DELISTED
Cymabay Therapeutics
CBAY
$9.46M 0.04%
2,170,464
– –
GTH
72
DELISTED
Genetron Holdings Limited ADS
GTH
$9.17M 0.04%
455,306
– –
CNTA
73
Centessa Pharmaceuticals
CNTA
$2.13B
$8.88M 0.04%
+400,000
New +$8.88M
ISEE
74
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
$8.87M 0.04%
1,406,037
– –
ATHA icon
75
Athira Pharma
ATHA
$15.5M
$8.26M 0.04%
806,367
– –
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3
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