Baker Bros. Advisors’s Xenon Pharmaceuticals XENE Stock Holding History

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$21.5M	Hold	370,208	–	–	0.12%	50
2025 Q4	$16.6M	Hold	370,208	–	–	0.1%	59
2025 Q3	$14.9M	Hold	370,208	–	–	0.11%	53
2025 Q2	$11.6M	Buy	370,208 +22,800	+7%	+$744K	0.11%	50
2025 Q1	$11.7M	Sell	347,408 -646,271	-65%	-$24.5M	0.13%	43
2024 Q4	$39M	Hold	993,679	–	–	0.42%	30
2024 Q3	$39.1M	Hold	993,679	–	–	0.41%	29
2024 Q2	$38.7M	Hold	993,679	–	–	0.5%	27
2024 Q1	$42.8M	Hold	993,679	–	–	0.54%	30
2023 Q4	$45.8M	Buy	993,679 +242,040	+32%	+$8.55M	0.52%	24
2023 Q3	$25.7M	Hold	751,639	–	–	0.15%	33
2023 Q2	$28.9M	Hold	751,639	–	–	0.17%	34
2023 Q1	$26.9M	Hold	751,639	–	–	0.15%	32
2022 Q4	$29.6M	Hold	751,639	–	–	0.18%	31
2022 Q3	$27.1M	Hold	751,639	–	–	0.18%	37
2022 Q2	$22.9M	Hold	751,639	–	–	0.13%	44
2022 Q1	$23M	Hold	751,639	–	–	0.13%	50
2021 Q4	$23.5M	Hold	751,639	–	–	0.11%	54
2021 Q3	$11.5M	Hold	751,639	–	–	0.05%	77
2021 Q2	$14M	Hold	751,639	–	–	0.06%	71
2021 Q1	$13.5M	Buy	751,639 +64,253	+9%	+$1.09M	0.06%	69
2020 Q4	$10.6M	Sell	687,386 -72,922	-10%	-$853K	0.04%	73
2020 Q3	$8.42M	Sell	760,308 -38,794	-5%	-$456K	0.03%	70
2020 Q2	$10M	Buy	+799,102	New	+$10.2M	0.04%	60