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Xenon Pharmaceuticals

206 hedge funds and large institutions have $2.58B invested in Xenon Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 69 increasing their positions, 73 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

114% more call options, than puts

Call options by funds: $14.8M | Put options by funds: $6.93M

8% more funds holding in top 10

Funds holding in top 10: 1314 (+1)

0.14% more ownership

Funds ownership: 100.08%100.23% (+0.14%)

5% less repeat investments, than reductions

Existing positions increased: 69 | Existing positions reduced: 73

1% less funds holding

Funds holding: 209206 (-3)

13% less first-time investments, than exits

New positions opened: 20 | Existing positions closed: 23

14% less capital invested

Capital invested by funds: $2.99B → $2.58B (-$415M)

Holders
206
Holders Change
-3
Holders Change %
-1.44%
% of All Funds
2.76%
Holding in Top 10
14
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+7.69%
% of All Funds
0.19%
New
20
Increased
69
Reduced
73
Closed
23
Calls
$14.8M
Puts
$6.93M
Net Calls
+$7.9M
Net Calls Change
+$3.62M
Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$278M +$28.9M +762,209 +10%
ACA
2
Avoro Capital Advisors
New York
$193M +$2.85M +75,000 +1%
DCM
3
Driehaus Capital Management
Illinois
$154M +$2.44M +64,264 +1%
Wellington Management Group
4
Wellington Management Group
Massachusetts
$127M +$440K +11,586 +0.3%
Janus Henderson Group
5
Janus Henderson Group
United Kingdom
$114M +$17.4M +458,338 +16%
Capital International Investors
6
Capital International Investors
California
$104M +$20.6M +541,520 +21%
B
7
Braidwell
Connecticut
$90.9M -$7.75M -204,089 -7%
PCH
8
Polar Capital Holdings
United Kingdom
$88M -$2.83M -74,618 -3%
CC
9
Commodore Capital
New York
$78M -$15.8M -415,000 -15%
Capital World Investors
10
Capital World Investors
California
$74.6M -$2.65M -69,822 -3%
BlackRock
11
BlackRock
New York
$68.3M -$2.62M -69,111 -3%
Adage Capital Partners
12
Adage Capital Partners
Massachusetts
$64.2M +$1.95M +51,276 +3%
Pictet Asset Management
13
Pictet Asset Management
Switzerland
$49.6M -$717K -18,894 -1%
Westfield Capital Management
14
Westfield Capital Management
Massachusetts
$46.7M +$8.89M +234,181 +20%
JP Morgan Chase
15
JP Morgan Chase
New York
$45.5M +$26.8K +707 +0.1%
AllianceBernstein
16
AllianceBernstein
Tennessee
$44.6M -$4.32M -113,794 -8%
AAA
17
Affinity Asset Advisors
New York
$44.6M +$6.34M +166,938 +14%
VPC
18
Vestal Point Capital
New York
$43.6M +$18.6M +490,000 +60%
SC
19
Samlyn Capital
New York
$34.1M -$55.3K -1,457 -0.1%
DTC
20
Deep Track Capital
Connecticut
$33.5M +$31.5M +830,868 +491%
O
21
OrbiMed
New York
$31.8M
RSCM
22
Rock Springs Capital Management
Maryland
$31.3M -$12.2M -320,178 -26%
T. Rowe Price Investment Management
23
T. Rowe Price Investment Management
Maryland
$26.7M -$24.3M -640,845 -45%
Jennison Associates
24
Jennison Associates
New York
$26.1M -$944K -24,860 -3%
Marshall Wace
25
Marshall Wace
United Kingdom
$25.4M -$5.38M -141,573 -16%

XENE Hedge Fund Activity: Q1 2025 in Review

206 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Xenon Pharmaceuticals (XENE) for Q1 2025, worth a combined $2.58B — down 14% from $2.99B a quarter earlier.

Sellers outnumbered buyers: 23 funds closed out of XENE and 20 opened new positions — a net loss of 3 holders — while 73 trimmed existing stakes and 69 added.

The largest buyer was Deep Track Capital, adding an estimated $31.5M. The largest seller was Baker Bros. Advisors, cutting an estimated $24.5M.

  • 206 institutional investors held Xenon Pharmaceuticals (XENE) as of Q1 2025, down from 209 in Q4 2024.
  • Funds reported $2.58B of Xenon Pharmaceuticals stock for Q1 2025, down 14% quarter-over-quarter.
  • 20 funds opened new Xenon Pharmaceuticals positions in Q1 2025 and 23 closed out, a net change of -3 holders.
  • The largest Xenon Pharmaceuticals buyer in Q1 2025 was Deep Track Capital, an estimated $31.5M added.
  • The largest Xenon Pharmaceuticals seller in Q1 2025 was Baker Bros. Advisors, an estimated $24.5M sold.

Based on aggregated 13F filings for Q1 2025.