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Xenon Pharmaceuticals
XENE

Overview Fund Activity

206 hedge funds and large institutions have $2.58B invested in Xenon Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 68 increasing their positions, 73 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
206
Holders Change
-3
Holders Change %
-1.44%
% of All Funds
2.8%
Holding in Top 10
14
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+7.69%
% of All Funds
0.19%
New
20
Increased
68
Reduced
73
Closed
23
Calls
$14.8M
Puts
$6.93M
Net Calls
+$7.9M
Net Calls Change
+$3.62M

Top Buyers

1
DTC
Deep Track Capital
Connecticut
+$27.9M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$25.6M
3
LGM
Logos Global Management
California
+$21.8M
4
Capital International Investors
Capital International Investors
California
+$18.2M
5
VPC
Vestal Point Capital
New York
+$16.4M

Top Sellers

1
BBA
Baker Bros. Advisors
New York
-$21.7M
2
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
-$21.5M
3
FLAM
First Light Asset Management
Minnesota
-$17.9M
4
CC
Commodore Capital
New York
-$13.9M
5
Federated Hermes
Federated Hermes
Pennsylvania
-$10.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$278M +$25.6M +762,209 +10%
ACA
2
Avoro Capital Advisors
New York
$193M +$2.52M +75,000 +1%
DCM
3
Driehaus Capital Management
Illinois
$154M +$2.16M +64,264 +1%
Wellington Management Group
4
Wellington Management Group
Massachusetts
$127M +$389K +11,586 +0.3%
Janus Henderson Group
5
Janus Henderson Group
United Kingdom
$114M +$15.7M +458,338 +16%
Capital International Investors
6
Capital International Investors
California
$104M +$18.2M +541,520 +21%
B
7
Braidwell
Connecticut
$90.9M -$6.85M -204,089 -7%
PCH
8
Polar Capital Holdings
United Kingdom
$88M -$2.5M -74,618 -3%
CC
9
Commodore Capital
New York
$78M -$13.9M -415,000 -15%
Capital World Investors
10
Capital World Investors
California
$74.6M -$2.34M -69,822 -3%
BlackRock
11
BlackRock
New York
$68.3M -$2.32M -69,111 -3%
Adage Capital Partners
12
Adage Capital Partners
Massachusetts
$64.2M +$1.72M +51,276 +3%
Pictet Asset Management
13
Pictet Asset Management
Switzerland
$49.6M -$634K -18,894 -1%
Westfield Capital Management
14
Westfield Capital Management
Massachusetts
$46.7M +$7.86M +234,181 +20%
JPMorgan Chase & Co
15
JPMorgan Chase & Co
New York
$45.5M +$23.7K +707 +0.1%
AllianceBernstein
16
AllianceBernstein
Tennessee
$44.6M -$3.82M -113,794 -8%
AAA
17
Affinity Asset Advisors
New York
$44.6M +$5.6M +166,938 +14%
VPC
18
Vestal Point Capital
New York
$43.6M +$16.4M +490,000 +60%
SC
19
Samlyn Capital
New York
$34.1M -$48.9K -1,457 -0.1%
DTC
20
Deep Track Capital
Connecticut
$33.6M +$27.9M +830,868 +491%
O
21
OrbiMed
New York
$31.8M – – –
RSCM
22
Rock Springs Capital Management
Maryland
$31.3M -$10.7M -320,178 -26%
T. Rowe Price Investment Management
23
T. Rowe Price Investment Management
Maryland
$26.7M -$21.5M -640,845 -45%
Jennison Associates
24
Jennison Associates
New York
$26.1M -$834K -24,860 -3%
Marshall Wace
25
Marshall Wace
United Kingdom
$25.4M -$4.75M -141,573 -16%
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