Baker Bros. Advisors’s Albireo Pharma, Inc. Common Stock ALBO Stock Holding History

Quarter	Market Value	Status	Shares	Shares Change %	Trade Value	Portfolio Weight	Portfolio Position
2022 Q1	–	Sell	-104,521	Closed	-$2.43M	–	120
2021 Q4	$2.43M	Sell	104,521 -307,945	-75%	-$7.17M	0.01%	104
2021 Q3	$12.9M	Hold	412,466	–	–	0.06%	71
2021 Q2	$14.5M	Hold	412,466	–	–	0.06%	70
2021 Q1	$14.5M	Hold	412,466	–	–	0.06%	68
2020 Q4	$15.5M	Sell	412,466 -136,581	-25%	-$5.12M	0.06%	65
2020 Q3	$18.3M	Buy	549,047 +180,000	+49%	+$6.01M	0.07%	55
2020 Q2	$9.78M	Hold	369,047	–	–	0.04%	62
2020 Q1	$6.04M	Buy	369,047 +119,047	+48%	+$1.95M	0.04%	61
2019 Q4	$6.36M	Hold	250,000	–	–	0.03%	63
2019 Q3	$5M	Hold	250,000	–	–	0.03%	61
2019 Q2	$8.06M	Hold	250,000	–	–	0.05%	56
2019 Q1	$8.05M	Hold	250,000	–	–	0.05%	52
2018 Q4	$6.13M	Hold	250,000	–	–	0.05%	54
2018 Q3	$8.24M	Hold	250,000	–	–	0.05%	56
2018 Q2	$8.88M	Hold	250,000	–	–	0.07%	57
2018 Q1	$8.14M	Buy	250,000 +50,000	+25%	+$1.63M	0.07%	66
2017 Q4	$5.12M	Hold	200,000	–	–	0.04%	76
2017 Q3	$4.19M	Hold	200,000	–	–	0.03%	81
2017 Q2	$4.12M	Buy	+200,000	New	+$4.12M	0.04%	67
2015 Q2	–	Sell	-30,179	Closed	-$36K	–	133
2015 Q1	$36K	Buy	+30,179	New	+$36K	﹤0.01%	130
2013 Q3	–	Sell	-229,885	Closed	-$961K	–	84
2013 Q2	$961K	Buy	+229,885	New	+$961K	0.02%	68