BBA

Baker Bros. Advisors Portfolio holdings

AUM $10.3B
This Quarter Return
-6.77%
1 Year Return
+63.34%
3 Year Return
+231.6%
5 Year Return
+293.68%
10 Year Return
+1,612.7%
AUM
$23.1B
AUM Growth
+$23.1B
Cap. Flow
-$142M
Cap. Flow %
-0.62%
Top 10 Hldgs %
80.48%
Holding
138
New
11
Increased
23
Reduced
15
Closed
12

Top Buys

1
IMCR icon
Immunocore
IMCR
$107M
2
TIL icon
Instil Bio
TIL
$97.7M
3
TLIS
Talis Biomedical Corporation Common Stock
TLIS
$97.3M
4
GBT
Global Blood Therapeutics, Inc.
GBT
$93.6M
5
DSGN icon
Design Therapeutics
DSGN
$43M

Top Sells

1
ALXN
Alexion Pharmaceuticals Inc
ALXN
$729M
2
ADPT icon
Adaptive Biotechnologies
ADPT
$22.5M
3
GWPH
GW Pharmaceuticals Plc American Depositary Shares
GWPH
$13M
4
FPRX
Five Prime Therapeutics, Inc.
FPRX
$11.4M
5
AMRN
Amarin Corp
AMRN
$9.55M

Sector Composition

1 Healthcare 97.06%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
ALGS icon
51
Aligos Therapeutics
ALGS
$74.4M
$36.6M 0.16%
1,610,000
– –
AXSM icon
52
Axsome Therapeutics
AXSM
$6.12B
$35.6M 0.15%
628,414
-150,420
-19% -$8.52M
ADCT icon
53
ADC Therapeutics
ADCT
$357M
$34.6M 0.15%
1,418,107
– –
CCXI
54
DELISTED
ChemoCentryx, Inc.
CCXI
$33.7M 0.15%
656,710
– –
OPT
55
DELISTED
Opthea Limited American Depositary Shares
OPT
$31.7M 0.14%
3,308,705
– –
SYRE icon
56
Spyre Therapeutics
SYRE
$1.03B
$27M 0.12%
3,410,106
– –
NVAX icon
57
Novavax
NVAX
$1.24B
$26.1M 0.11%
143,756
-25,950
-15% -$4.7M
ALKS icon
58
Alkermes
ALKS
$5.08B
$22.9M 0.1%
1,228,170
-306,979
-20% -$5.73M
MREO
59
Mereo BioPharma
MREO
$281M
$22.6M 0.1%
6,719,948
+689,655
+11% +$2.32M
RETA
60
DELISTED
Reata Pharmaceuticals, Inc. Class A Common Stock
RETA
$22.3M 0.1%
223,976
– –
OTIC
61
DELISTED
Otonomy, Inc.
OTIC
$18.4M 0.08%
+7,220,074
New +$18.4M
AUPH icon
62
Aurinia Pharmaceuticals
AUPH
$1.54B
$18.3M 0.08%
1,410,064
– –
EWTX icon
63
Edgewise Therapeutics
EWTX
$1.54B
$16.3M 0.07%
+500,000
New +$16.3M
XNCR icon
64
Xencor
XNCR
$586M
$15.9M 0.07%
369,370
– –
ATHA icon
65
Athira Pharma
ATHA
$15.2M
$14.8M 0.06%
806,367
– –
ALBO
66
DELISTED
Albireo Pharma, Inc. Common Stock
ALBO
$14.5M 0.06%
412,466
– –
XENE icon
67
Xenon Pharmaceuticals
XENE
$3.04B
$13.5M 0.06%
751,639
+64,253
+9% +$1.15M
MIRM icon
68
Mirum Pharmaceuticals
MIRM
$3.79B
$12.8M 0.06%
647,313
– –
KDNY
69
DELISTED
Chinook Therapeutics, Inc. Common Stock
KDNY
$11.6M 0.05%
748,693
– –
SPRY icon
70
ARS Pharmaceuticals
SPRY
$1.09B
$10.4M 0.05%
238,095
– –
RVMD icon
71
Revolution Medicines
RVMD
$7.5B
$10.2M 0.04%
+222,222
New +$10.2M
CBAY
72
DELISTED
Cymabay Therapeutics
CBAY
$9.85M 0.04%
2,170,464
-722,812
-25% -$3.28M
GTH
73
DELISTED
Genetron Holdings Limited ADS
GTH
$9.77M 0.04%
455,306
– –
HOOK
74
DELISTED
HOOKIPA Pharma
HOOK
$9.42M 0.04%
700,481
– –
CRNX icon
75
Crinetics Pharmaceuticals
CRNX
$3.24B
$9.42M 0.04%
616,520
– –
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3
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