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SYRS

Syros Pharmaceuticals, Inc. Common Stock

Delisted

SYRS was delisted on the 19th of March, 2025.

70 hedge funds and large institutions have $291M invested in Syros Pharmaceuticals, Inc. Common Stock in 2019 Q4 according to their latest regulatory filings, with 17 funds opening new positions, 31 increasing their positions, 14 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

121% more repeat investments, than reductions

Existing positions increased: 31 | Existing positions reduced: 14

89% more first-time investments, than exits

New positions opened: 17 | Existing positions closed: 9

13% more funds holding

Funds holding: 6270 (+8)

0% more funds holding in top 10

Funds holding in top 10: 33 (0)

35% less capital invested

Capital invested by funds: $446M → $291M (-$156M)

Holders
70
Holders Change
+8
Holders Change %
+12.9%
% of All Funds
1.38%
Holding in Top 10
3
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.06%
New
17
Increased
31
Reduced
14
Closed
9
Calls
$956K
Puts
Net Calls
+$956K
Net Calls Change
-$592K
Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$42.4M +$2.73K +45 +0%
AIM
2
ARK Investment Management
Florida
$35.1M +$7.54M +124,308 +32%
NAMA
3
Nikko Asset Management Americas
New York
$34.4M +$2.07M +34,089 +7%
Sumitomo Mitsui Trust Group
4
Sumitomo Mitsui Trust Group
Japan
$34.4M +$2.07M +34,089 +7%
AVM
5
Arch Venture Management
Illinois
$22.9M -$3.28M -54,123 -14%
FP
6
Flagship Pioneering
Massachusetts
$20.3M
BlackRock
7
BlackRock
New York
$19.8M +$720K +11,865 +4%
Vanguard Group
8
Vanguard Group
Pennsylvania
$12.4M +$8.55K +141 +0.1%
SB
9
Samsara BioCapital
California
$11.3M
DM
10
Deerfield Management
New York
$8.77M
JP Morgan Chase
11
JP Morgan Chase
New York
$6.54M +$3.19M +52,550 +125%
BBA
12
Baker Bros. Advisors
New York
$4.77M -$1.73M -28,467 -29%
State Street
13
State Street
Massachusetts
$4.72M +$52.8K +870 +1%
Millennium Management
14
Millennium Management
New York
$3.63M +$3.07M +50,681 +2,699%
Dimensional Fund Advisors
15
Dimensional Fund Advisors
Texas
$3.47M +$163K +2,691 +6%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$3.29M +$146K +2,412 +5%
SCM
17
Sio Capital Management
New York
$3.1M +$2.72M +44,853 New
Northern Trust
18
Northern Trust
Illinois
$2.77M -$154K -2,535 -6%
PCM
19
Portolan Capital Management
Massachusetts
$2.26M +$1.98M +32,685 New
RG
20
Redmile Group
California
$1.47M -$22.3M -367,646 -95%
Charles Schwab
21
Charles Schwab
California
$1.42M +$38K +626 +3%
D.E. Shaw & Co
22
D.E. Shaw & Co
New York
$1.02M +$450K +7,414 +102%
N
23
Nuveen
North Carolina
$972K +$200K +3,299 +31%
Renaissance Technologies
24
Renaissance Technologies
New York
$892K -$955K -15,751 -55%
Bank of New York Mellon
25
Bank of New York Mellon
New York
$770K -$667 -11 -0.1%

SYRS Hedge Fund Activity: Q4 2019 in Review

70 of the 5,076 institutional investors tracked by Wall St. Rank reported a position in Syros Pharmaceuticals, Inc. Common Stock (SYRS) for Q4 2019, worth a combined $291M — down 35% from $446M a quarter earlier.

Buyers outnumbered sellers: 17 funds opened new SYRS positions and 9 closed out — a net gain of 8 holders — while 31 added to existing stakes and 14 trimmed.

The largest buyer was ARK Investment Management, adding an estimated $7.54M. The largest seller was Redmile Group, cutting an estimated $22.3M.

  • 70 institutional investors held Syros Pharmaceuticals, Inc. Common Stock (SYRS) as of Q4 2019, up from 62 in Q3 2019.
  • Funds reported $291M of Syros Pharmaceuticals, Inc. Common Stock stock for Q4 2019, down 35% quarter-over-quarter.
  • 17 funds opened new Syros Pharmaceuticals, Inc. Common Stock positions in Q4 2019 and 9 closed out, a net change of +8 holders.
  • The largest Syros Pharmaceuticals, Inc. Common Stock buyer in Q4 2019 was ARK Investment Management, an estimated $7.54M added.
  • The largest Syros Pharmaceuticals, Inc. Common Stock seller in Q4 2019 was Redmile Group, an estimated $22.3M sold.

Based on aggregated 13F filings for Q4 2019.