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SYRS

Syros Pharmaceuticals, Inc. Common Stock

Delisted

SYRS was delisted on the 19th of March, 2025.

90 hedge funds and large institutions have $166M invested in Syros Pharmaceuticals, Inc. Common Stock in 2021 Q4 according to their latest regulatory filings, with 12 funds opening new positions, 31 increasing their positions, 31 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed

0% more funds holding in top 10

Funds holding in top 10: 11 (0)

0% more repeat investments, than reductions

Existing positions increased: 31 | Existing positions reduced: 31

10% less funds holding

Funds holding: 10090 (-10)

26% less capital invested

Capital invested by funds: $223M → $166M (-$57.1M)

45% less first-time investments, than exits

New positions opened: 12 | Existing positions closed: 22

66% less call options, than puts

Call options by funds: $85K | Put options by funds: $249K

Holders
90
Holders Change
-10
Holders Change %
-10%
% of All Funds
1.39%
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.02%
New
12
Increased
31
Reduced
31
Closed
22
Calls
$85K
Puts
$249K
Net Calls
-$164K
Net Calls Change
+$1.16M
Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$29.5M +$9.92K +245 +0%
BCLSI
2
Bain Capital Life Sciences Investors
Massachusetts
$20.4M +$1.94M +47,938 +8%
BlackRock
3
BlackRock
New York
$13.8M -$492K -12,140 -3%
ABG
4
Ally Bridge Group
New York
$11.5M +$405K +10,000 +3%
AG
5
Artal Group
Luxembourg
$9.78M +$4.05M +100,000 +50%
FP
6
Flagship Pioneering
Massachusetts
$9.58M
Vanguard Group
7
Vanguard Group
Pennsylvania
$9.1M -$792K -19,561 -7%
OFM
8
Omega Fund Management
Massachusetts
$8.19M
SB
9
Samsara BioCapital
California
$6.24M
Adage Capital Partners
10
Adage Capital Partners
Massachusetts
$6.19M +$405K +10,000 +6%
O
11
OrbiMed
New York
$5.99M
ACM
12
Altium Capital Management
New York
$3.78M -$455K -11,241 -9%
State Street
13
State Street
Massachusetts
$3.75M +$135K +3,337 +3%
Geode Capital Management
14
Geode Capital Management
Massachusetts
$3.11M +$387K +9,555 +11%
SCM
15
Sio Capital Management
New York
$2.94M
RCM
16
RA Capital Management
Massachusetts
$2.93M
CS
17
Candriam SCA
Luxembourg
$1.91M
Northern Trust
18
Northern Trust
Illinois
$1.71M +$810 +20 +0%
LCP
19
LGT Capital Partners
Switzerland
$1.63M +$1.85M +45,661 +1,052%
Goldman Sachs
20
Goldman Sachs
New York
$1.61M +$17.8K +439 +0.9%
Dimensional Fund Advisors
21
Dimensional Fund Advisors
Texas
$1.03M +$445K +10,990 +54%
Los Angeles Capital Management
22
Los Angeles Capital Management
California
$840K -$5.06K -125 -0.5%
GCP
23
GSA Capital Partners
United Kingdom
$789K +$534K +13,179 +119%
Bank of New York Mellon
24
Bank of New York Mellon
New York
$633K -$8.5K -210 -1%
N
25
Nuveen
North Carolina
$611K -$72.8K -1,799 -9%

SYRS Hedge Fund Activity: Q4 2021 in Review

90 of the 6,498 institutional investors tracked by Wall St. Rank reported a position in Syros Pharmaceuticals, Inc. Common Stock (SYRS) for Q4 2021, worth a combined $166M — down 26% from $223M a quarter earlier.

Sellers outnumbered buyers: 22 funds closed out of SYRS and 12 opened new positions — a net loss of 10 holders — while 31 trimmed existing stakes and 31 added.

The largest buyer was Artal Group, adding an estimated $4.05M. The largest seller was Millennium Management, cutting an estimated $907K.

  • 90 institutional investors held Syros Pharmaceuticals, Inc. Common Stock (SYRS) as of Q4 2021, down from 100 in Q3 2021.
  • Funds reported $166M of Syros Pharmaceuticals, Inc. Common Stock stock for Q4 2021, down 26% quarter-over-quarter.
  • 12 funds opened new Syros Pharmaceuticals, Inc. Common Stock positions in Q4 2021 and 22 closed out, a net change of -10 holders.
  • The largest Syros Pharmaceuticals, Inc. Common Stock buyer in Q4 2021 was Artal Group, an estimated $4.05M added.
  • The largest Syros Pharmaceuticals, Inc. Common Stock seller in Q4 2021 was Millennium Management, an estimated $907K sold.

Based on aggregated 13F filings for Q4 2021.