SEPN

Septerna, Inc. Common Stock
SEPN

Overview Fund Activity

89 hedge funds and large institutions have $470M invested in Septerna, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 31 increasing their positions, 19 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
89
Holders Change
+18
Holders Change %
+25.35%
% of All Funds
1.19%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
25
Increased
31
Reduced
19
Closed
6
Calls
$440K
Puts
$12.6M
Net Calls
-$12.1M
Net Calls Change
-$11.9M

Top Buyers

1
DCM
Driehaus Capital Management
Illinois
$49.5M
2
PA
Perceptive Advisors
New York
$5.72M
3
VA
VR Adviser
New York
$5.71M
4
Vanguard Group
Vanguard Group
Pennsylvania
$14.9M
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
$1.76M

Top Sellers

1
DTC
Deep Track Capital
Connecticut
$1.29M
2
CCM
Catalio Capital Management
New York
$3.11M
3
SCM
Soleus Capital Management
Connecticut
$798K
4
Millennium Management
Millennium Management
New York
$549K
5
WP
Woodline Partners
California
$2.99M
Name Holding Trade Value Shares
Change 		Shares
Change %
DTC
26
Deep Track Capital
Connecticut
$1.29M -$18.9M -1,791,213 -94%
LGM
27
Logos Global Management
California
$1.15M -$264K -25,000 -19%
Bank of America
28
Bank of America
North Carolina
$1.05M +$927K +87,654 +758%
Morgan Stanley
29
Morgan Stanley
New York
$897K -$65.4K -6,184 -7%
Two Sigma Investments
30
Two Sigma Investments
New York
$821K +$29.6K +2,801 +4%
SCM
31
Soleus Capital Management
Connecticut
$798K -$7.14M -675,897 -90%
UBS Group
32
UBS Group
Switzerland
$765K -$1.77M -167,595 -70%
RC
33
Rangeley Capital
Connecticut
$619K +$59.8K +5,655 +11%
NL
34
Nuveen LLC
North Carolina
$613K +$359K +34,010 +142%
Millennium Management
35
Millennium Management
New York
$549K -$4.07M -384,620 -88%
Bank of New York Mellon
36
Bank of New York Mellon
New York
$513K +$107K +10,113 +26%
Barclays
37
Barclays
United Kingdom
$377K +$137K +12,973 +57%
Alyeska Investment Group
38
Alyeska Investment Group
Illinois
$370K – – –
UBS AM
39
UBS AM
Illinois
$303K +$303K +28,700 New
RhumbLine Advisers
40
RhumbLine Advisers
Massachusetts
$302K +$55.5K +5,254 +23%
T. Rowe Price Associates
41
T. Rowe Price Associates
Maryland
$264K +$20.6K +1,945 +8%
BFM
42
Boothbay Fund Management
New York
$255K +$255K +24,142 New
GCP
43
GSA Capital Partners
United Kingdom
$249K +$55.3K +5,228 +29%
Simplex Trading
44
Simplex Trading
Illinois
$248K +$248K +23,495 +78,317%
XT
45
XTX Topco
Cayman Islands
$236K -$159K -15,020 -40%
AllianceBernstein
46
AllianceBernstein
Tennessee
$234K +$234K +22,100 New
Citadel Advisors
47
Citadel Advisors
Florida
$188K +$188K +17,774 New
Tudor Investment Corp
48
Tudor Investment Corp
Connecticut
$177K +$177K +16,761 New
Wells Fargo
49
Wells Fargo
California
$156K +$40.7K +3,848 +35%
MIM
50
MetLife Investment Management
New Jersey
$145K +$145K +13,685 New
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