Barclays
SEPN

Barclays’s Septerna Inc SEPN Stock Holding History

Barclays’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$546K Sell
22,714
-15,433
-40% -$406K ﹤0.01% 3149
2025
Q4 		$1.06M Buy
38,147
+8,045
+27% +$192K ﹤0.01% 3389
2025
Q3 		$566K Sell
30,102
-5,604
-16% -$73.5K ﹤0.01% 3729
2025
Q2 		$377K Buy
35,706
+12,973
+57% +$107K ﹤0.01% 3916
2025
Q1 		$132K Sell
22,733
-6,052
-21% -$69.1K ﹤0.01% 4290
2024
Q4 		$659K Buy
+28,785
New +$681K ﹤0.01% 3653

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Barclays's SEPN Position: Q1 2026 in Review

Barclays reduced its Septerna Inc (SEPN) stake by 40% in Q1 2026, selling an estimated $406K and leaving 22,714 shares worth $546K. The position accounts for ﹤0.01% of the portfolio, ranked #3149.

Barclays first reported a position in SEPN in Q4 2024 and has held it in 6 quarters since. The position peaked at $1.06M in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • Barclays held 22,714 shares of Septerna Inc worth $546K as of Q1 2026.
  • Barclays sold 15,433 Septerna Inc shares in Q1 2026, an estimated $406K.
  • Septerna Inc made up ﹤0.01% of Barclays's portfolio in Q1 2026, its #3149 holding.
  • Barclays first reported a position in Septerna Inc in Q4 2024 and has held it in 6 quarters since.
  • Barclays's Septerna Inc position peaked at $1.06M in Q4 2025.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Barclays's 13F filing for Q1 2026, filed 15 May 2026.